Concepedia

Thresholds For Genotoxicity

Thresholds for Genotoxicity is a theoretical framework in regulatory toxicology that identifies the lowest dose or exposure level at which a substance elicits measurable genotoxic effects, distinguishing it from non-threshold mechanisms by assuming a definable point of biological response below which DNA damage does not occur.

31

Publications

1.5K

Citations

106

Authors

56

Institutions

Publications per year

2017–2026

1

Parents

Publications

31

Genotoxicity risk assessment: a proposed classification strategy

Kerry L. Dearfield, Michael C. Cimino, Nancy McCarroll et al. · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · 2002 · 152 citations

, , +12

The genotoxic disease syndrome

Branko Kurelec · Marine Environmental Research · 1993 · 139 citations

, , +9

IWGT report on quantitative approaches to genotoxicity risk assessment II. Use of point-of-departure (PoD) metrics in defining acceptable exposure limits and assessing human risk

James T. MacGregor, Roland Frötschl, Paul A. White et al. · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · 2014 · 127 citations · Full text

, , +16

Do dose response thresholds exist for genotoxic alkylating agents?

Gareth Jenkins, Shareen H. Doak, George E. Johnson et al. · Mutagenesis · 2005 · 118 citations · Full text

, , +15

In vivo studies in the mouse to define a threshold for the genotoxicity of EMS and ENU

Elmar Gocke, Lutz Müller · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · 2009 · 103 citations

, , +9

1–5 of 31

Authors

106

  1. DK
    David Kirkland

    Covance (United Kingdom), United Kingdom

    4 publications · 77 citations

    4

    h-index

  2. GJ
    Gareth Jenkins

    Swansea University, United Kingdom

    3 publications · 181 citations

    3

    h-index

  3. GE
    George E. Johnson

    Swansea University, United Kingdom

    3 publications · 257 citations

    3

    h-index

  4. JM
    James M. Parry

    Swansea University, United Kingdom

    3 publications · 199 citations

    3

    h-index

  5. JT
    James T. MacGregor

    Western Regional Research Center, United States

    2 publications · 156 citations

    2

    h-index

1–5 of 106

Institutions

56

  1. Swansea University

    Swansea, United Kingdom

    5 h-index

    17 publications

    638 citations

  2. Roche (Switzerland)

    Basel, Switzerland

    4 h-index

    8 publications

    577 citations

  3. Covance (United Kingdom)

    Harrogate, United Kingdom

    4 h-index

    4 publications

    77 citations

  4. Unilever (United Kingdom)

    London, United Kingdom

    3 h-index

    3 publications

    126 citations

  5. University of Wales

    Cardiff, United Kingdom

    2 h-index

    6 publications

    285 citations

  6. Pfizer (United States)

    New York, United States

    2 h-index

    5 publications

    187 citations

  7. Vrije Universiteit Brussel

    Brussels, Belgium

    2 h-index

    3 publications

    72 citations

  8. Health Canada

    Ottawa, Canada

    2 h-index

    2 publications

    156 citations

1–8 of 56

Venues

  1. 10

    h-index

  2. 3

    h-index

  3. Mutagenesis

    2 publications · 216 citations

    2

    h-index

  4. Food and Chemical Toxicology

    2 publications · 65 citations

    2

    h-index

  5. 1

    h-index

1–5