Concepedia

Thiol-binding Drugs

Thiol-Binding Drugs is a pharmacological agent that selectively forms disulfide bonds with cysteine moieties in urinary cystine to enhance its solubility, thereby preventing the formation of cystine stones in the context of cystinuria.

88

Publications

3.4K

Citations

402

Authors

129

Institutions

Publications per year

2017–2026

16

Parents

Publications

88

Probing the Cysteine-34 Position of Endogenous Serum Albumin with Thiol-Binding Doxorubicin Derivatives. Improved Efficacy of an Acid-Sensitive Doxorubicin Derivative with Specific Albumin-Binding Properties Compared to That of the Parent Compound

Felix Kratz, André Warnecke, Karin Scheuermann et al. · Journal of Medicinal Chemistry · 2002 · 271 citations

, , +15

(6-Maleimidocaproyl)hydrazone of doxorubicin. A new derivative for the preparation of immunoconjugates of doxorubicin

David Willner, Pamela A. Trail, Sandra J. Hofstead et al. · Bioconjugate Chemistry · 1993 · 222 citations

, , +17

Disulfiram is a DNA demethylating agent and inhibits prostate cancer cell growth

Jianqing Lin, Michael C. Haffner, Yonggang Zhang et al. · The Prostate · 2010 · 193 citations · Full text

, , +13

FDA-approved thiol-reacting drugs that potentially bind into the SARS-CoV-2 main protease, essential for viral replication

Naún Lobo-Galo, Manuel Terrazas-López, Alejandro Martı́nez-Martı́nez et al. · Journal of Biomolecular Structure and Dynamics · 2020 · 108 citations · Full text

, , +17

REGULATION OF TASTE ACUITY BY THIOLS AND METAL IONS

R.I. Henkin, Dan F. Bradley · Proceedings of the National Academy of Sciences · 1969 · 98 citations · Full text

, , +17

1–5 of 88

Authors

402

  1. JR
    John R. Asplin

    Link Foundation, United States

    4 publications · 169 citations

    4

    h-index

  2. DS
    David S. Goldfarb

    New York University, United States

    3 publications · 102 citations

    3

    h-index

  3. EM
    E Munthe

    Oslo University Hospital, Norway

    3 publications · 88 citations

    3

    h-index

  4. EJ
    Egil Jellum

    University of Oslo, Norway

    3 publications · 88 citations

    3

    h-index

  5. JA
    Jan Aaseth

    Innlandet Hospital Trust, Norway

    3 publications · 88 citations

    3

    h-index

1–5 of 402

Institutions

129

  1. Link Foundation

    Binghamton, United States

    4 h-index

    9 publications

    420 citations

  2. VA NY Harbor Healthcare System

    New York, United States

    3 h-index

    5 publications

    150 citations

  3. King's College London

    London, United Kingdom

    2 h-index

    2 publications

    82 citations

  4. University of Göttingen

    Göttingen, Germany

    2 h-index

    4 publications

    82 citations

  5. University of Arizona

    Tucson, United States

    2 h-index

    6 publications

    239 citations

  6. Kumamoto University

    Kumamoto, Japan

    2 h-index

    11 publications

    220 citations

  7. University of Southampton

    Southampton, United Kingdom

    2 h-index

    12 publications

    868 citations

  8. Vitalant

    Denver, United States

    2 h-index

    12 publications

    246 citations

1–8 of 129

Venues

  1. PubMed

    Repository · 5 publications · 168 citations

    5

    h-index

  2. Bioorganic & Medicinal Chemistry Letters

    4 publications · 115 citations

    4

    h-index

  3. Journal of Medicinal Chemistry

    4 publications · 433 citations

    4

    h-index

  4. The Journal of Urology

    4 publications · 178 citations

    4

    h-index

  5. Chemical Communications

    ChemComm · 2 publications · 74 citations

    2

    h-index

1–5