Concepedia

Thioether Linkers

Thioether Linkers is a type of chemical linker characterized by a stable carbon-sulfur-carbon (C–S–C) covalent bond formed through the reaction between a thiol group and an alkyl halide or maleimide, distinguished from other bioconjugation linkers by its resistance to hydrolysis and oxidation under physiological conditions.

206

Publications

8.5K

Citations

1K

Authors

346

Institutions

Publications per year

2017–2026

43

Parents

Publications

206

Novel thioether bond revealed by a 1.7 Å crystal structure of galactose oxidase

Nobutoshi Ito, Simon E. V. Phillips, Conrad Stevens et al. · Nature · 1991 · 755 citations

, , +13

Tumor Delivery and In Vivo Processing of Disulfide-Linked and Thioether-Linked Antibody−Maytansinoid Conjugates

Hans K. Erickson, Wayne C. Widdison, Michele Mayo et al. · Bioconjugate Chemistry · 2009 · 240 citations

, , +17

The Effect of Different Linkers on Target Cell Catabolism and Pharmacokinetics/Pharmacodynamics of Trastuzumab Maytansinoid Conjugates

Hans K. Erickson, Gail D. Lewis Phillips, Douglas D. Leipold et al. · Molecular Cancer Therapeutics · 2012 · 195 citations

, , +17

Anti-Thy 1.2 monoclonal antibody linked to ricin is a potent cell-type-specific toxin.

Richard J. Youle, David M. Neville · Proceedings of the National Academy of Sciences · 1980 · 192 citations · Full text

, , +17

Angiotensin-(1-7) with Thioether Bridge: An Angiotensin-Converting Enzyme-Resistant, Potent Angiotensin-(1-7) Analog

Leon Kluskens, S.Adriaan Nelemans, Rick Rink et al. · Journal of Pharmacology and Experimental Therapeutics · 2008 · 148 citations

, , +17

1–5 of 206

Authors

1K

  1. HK
    Hans K. Erickson

    ImmunoGen (United States), United States

    4 publications · 591 citations

    4

    h-index

  2. IB
    Igor B. Dawid

    National Institutes of Health, United States

    3 publications · 220 citations

    3

    h-index

  3. JM
    John M. Buchanan

    Massachusetts Institute of Technology, United States

    3 publications · 220 citations

    3

    h-index

  4. TC
    Thayer C. French

    Massachusetts Institute of Technology, United States

    3 publications · 220 citations

    3

    h-index

  5. GZ
    Gang Zhang

    Sichuan University, China

    3 publications · 58 citations

    3

    h-index

1–5 of 1K

Institutions

346

  1. Chinese Academy of Sciences

    Beijing, China

    7 h-index

    25 publications

    559 citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    6 h-index

    43 publications

    2.4K citations

  3. Sichuan University

    Chengdu, China

    4 h-index

    22 publications

    380 citations

  4. Eötvös Loránd University

    Budapest, Hungary

    3 h-index

    11 publications

    184 citations

  5. Saarland University

    Saarbrücken, Germany

    3 h-index

    7 publications

    83 citations

  6. Massachusetts Institute of Technology

    Cambridge, United States

    3 h-index

    9 publications

    614 citations

  7. University of Arizona

    Tucson, United States

    3 h-index

    14 publications

    664 citations

  8. Shanghai Jiao Tong University

    Shanghai, China

    3 h-index

    16 publications

    541 citations

1–8 of 346

Venues

  1. Tetrahedron Letters

    14 publications · 512 citations

    13

    h-index

  2. Bioconjugate Chemistry

    8 publications · 589 citations

    8

    h-index

  3. Chemistry - A European Journal

    8 publications · 432 citations

    8

    h-index

  4. Journal of Biological Chemistry

    JBC · 7 publications · 566 citations

    7

    h-index

  5. The Journal of Organic Chemistry

    JOC · 7 publications · 184 citations

    7

    h-index

1–5