Concepedia

Thioamide Bioisosteres

Thioamide Bioisosteres is a class of classical bioisosteres in which a thioamide group (–C(=S)NH–) serves as a functional mimic of an amide group (–C(=O)NH–), differing in electronic and steric properties due to sulfur substitution at the carbonyl oxygen, thereby modulating physicochemical and pharmacokinetic characteristics of bioactive molecules.

39

Publications

973

Citations

203

Authors

80

Institutions

Publications per year

2017–2026

7

Parents

Publications

39

Thioamides in the collagen triple helix

Robert W. Newberry, Brett VanVeller, Ronald T. Raines · Chemical Communications · 2015 · 78 citations

, , +16

Rhodamine Inhibitors of P-Glycoprotein: An Amide/Thioamide “Switch” for ATPase Activity

Michael K. Gannon, Jason J. Holt, Stephanie M. Bennett et al. · Journal of Medicinal Chemistry · 2009 · 72 citations · Full text

, , +13

Synthesis and QSAR studies of novel triazole compounds containing thioamide as potential antifungal agents

Qingli Wei, Shu‐Sheng Zhang, Jun Gao et al. · Bioorganic & Medicinal Chemistry · 2006 · 61 citations

, , +14

A Novel Rhein Derivative Modulates Bone Formation and Resorption and Ameliorates Estrogen-Dependent Bone Loss

Min Jiang, Tianqi Wang, Xueming Yan et al. · Journal of Bone and Mineral Research · 2018 · 49 citations · Full text

, , +17

Thioamide substrate probes of metal-substrate interactions in carboxypeptidase a catalysis

Michael D. Bond, Barton Holmquist, Bert L. Vallée · Journal of Inorganic Biochemistry · 1986 · 43 citations

, , +13

1–5 of 39

Authors

203

  1. MH
    M. Hollósi

    Eötvös Loránd University, Hungary

    3 publications · 75 citations

    3

    h-index

  2. MZ
    M. Zewdu

    Institute of Organic Chemistry, Hungary

    2 publications · 56 citations

    2

    h-index

  3. ZM
    Zs. Majer

    Eötvös Loránd University, Hungary

    2 publications · 56 citations

    2

    h-index

  4. KE
    Katalin E. Kövér

    University of Debrecen, Hungary

    1 publications · 38 citations

    1

    h-index

  5. TW
    Tianqi Wang

    Jilin University, China

    1 publications · 49 citations

    1

    h-index

1–5 of 203

Institutions

80

  1. Eötvös Loránd University

    Budapest, Hungary

    3 h-index

    11 publications

    320 citations

  2. Chinese Academy of Sciences

    Beijing, China

    3 h-index

    9 publications

    229 citations

  3. Centre Paul Broca

    Paris, France

    2 h-index

    6 publications

    69 citations

  4. Institute of Organic Chemistry

    Budapest, Hungary

    2 h-index

    4 publications

    92 citations

  5. Utkal University

    Bhubaneswar, India

    1 h-index

    1 publications

    13 citations

  6. Centre National de la Recherche Scientifique

    Paris, France

    1 h-index

    4 publications

    40 citations

  7. Institute of Oceanology

    Qingdao, China

    1 h-index

    1 publications

    61 citations

  8. University of Arizona

    Tucson, United States

    1 h-index

    2 publications

    76 citations

1–8 of 80

Venues

  1. Bioorganic & Medicinal Chemistry Letters

    3 publications · 55 citations

    3

    h-index

  2. Tetrahedron

    3 publications · 74 citations

    3

    h-index

  3. Pharmaceutical Chemistry Journal

    2 publications · 21 citations

    2

    h-index

  4. Journal of Molecular Structure

    2 publications · 49 citations

    2

    h-index

  5. Chemistry - A European Journal

    2 publications · 49 citations

    2

    h-index

1–5