Concepedia

Therapeutic Tolerance

Therapeutic Tolerance is a pharmacological phenomenon within the broader category of drug tolerance, distinguished by a diminished therapeutic response to a drug over time despite consistent dosing, necessitating dose adjustments or treatment modifications to maintain clinical efficacy.

62

Publications

2.7K

Citations

234

Authors

102

Institutions

Publications per year

2017–2026

3

Parents

Publications

62

Acute tolerance to methylphenidate in the treatment of attention deficit hyperactivity disorder in children*

James M. Swanson, Suneel Gupta, Diane Guinta et al. · Clinical Pharmacology & Therapeutics · 1999 · 217 citations

, , +17

DEVELOPMENT AND LOSS OF TOLERANCE TO MORPHINE IN THE RAT AFTER SINGLE AND MULTIPLE INJECTIONS

Joseph Cochin, Conan Kornetsky · Journal of Pharmacology and Experimental Therapeutics · 1964 · 202 citations

, , +15

Pavlovian psychopharmacology: The associative basis of tolerance.

Shepard Siegel, Marco A. S. Baptista, Joseph A. Kim et al. · Experimental and Clinical Psychopharmacology · 2000 · 147 citations

, , +9

Differential tolerance to biological and subjective effects of four closely spaced doses of N,N-dimethyltryptamine in humans

Rick J. Strassman, Clifford Qualls, Laura M. Berg · Biological Psychiatry · 1996 · 129 citations

, , +13

Possible Mechanism of Tolerance to Narcotic Drugs

Julius Axelrod · Science · 1956 · 112 citations

, , +17

1–5 of 62

Authors

234

  1. CK
    Conan Kornetsky

    Boston University, United States

    2 publications · 274 citations

    2

    h-index

  2. BF
    Bernice Farrell

    Queen's University, Canada

    2 publications · 104 citations

    2

    h-index

  3. JG
    Johan Gabrielsson

    AstraZeneca (Sweden), Sweden

    2 publications · 103 citations

    2

    h-index

  4. JO
    John O. Parker

    Queen's University, Canada

    3 publications · 102 citations

    2

    h-index

  5. MW
    Monique Wakelkamp

    Karolinska Institutet, Sweden

    2 publications · 103 citations

    2

    h-index

1–5 of 234

Institutions

102

  1. National Institutes of Health

    Bethesda, United States

    2 h-index

    4 publications

    316 citations

  2. Karolinska University Hospital

    Stockholm, Sweden

    2 h-index

    2 publications

    103 citations

  3. United States Public Health Service

    Washington D.C., United States

    2 h-index

    6 publications

    367 citations

  4. University of Toronto

    Toronto, Canada

    2 h-index

    5 publications

    242 citations

  5. Karolinska Institutet

    Stockholm, Sweden

    2 h-index

    7 publications

    398 citations

  6. Queen's University

    Kingston, Canada

    2 h-index

    8 publications

    428 citations

  7. Harvard University

    Cambridge, United States

    2 h-index

    7 publications

    247 citations

  8. National Institute of Mental Health

    Bethesda, United States

    2 h-index

    3 publications

    142 citations

1–8 of 102

Venues

  1. 5

    h-index

  2. PubMed

    Repository · 4 publications · 139 citations

    4

    h-index

  3. Science

    3 publications · 208 citations

    3

    h-index

  4. Pharmacology Biochemistry and Behavior

    3 publications · 117 citations

    3

    h-index

  5. European Journal of Pharmacology

    EJP · 2 publications · 23 citations

    2

    h-index

1–5