Concepedia

Tetrazole Replacements

Tetrazole Replacements is a bioisosteric replacement strategy in medicinal chemistry that involves substituting the tetrazole ring—a five-membered aromatic heterocycle with four nitrogen atoms—for a carboxylic acid or other acidic functional group to modulate pharmacokinetic and pharmacodynamic properties while maintaining similar pKa and spatial configuration.

33

Publications

2.2K

Citations

238

Authors

51

Institutions

Publications per year

2017–2026

7

Parents

Publications

33

Substituent Effects on the Antibacterial Activity of Nitrogen−Carbon-Linked (Azolylphenyl)oxazolidinones with Expanded Activity Against the Fastidious Gram-Negative Organisms <i>Haemophilus </i><i>i</i><i>nfluenzae</i> and <i>Moraxella </i><i>c</i><i>atarrhalis</i>

Michaël Génin, Debra A. Allwine, David Anderson et al. · Journal of Medicinal Chemistry · 2000 · 726 citations

, , +14

Nonpeptide angiotensin II receptor antagonists: the discovery of a series of N-(biphenylylmethyl)imidazoles as potent, orally active antihypertensives

David J. Carini, John V. Duncia, Paul E. Aldrich et al. · Journal of Medicinal Chemistry · 1991 · 431 citations · Full text

, , +13

Synthesis of novel substituted tetrazoles having antifungal activity

Ram Shankar Upadhayaya, Sanjay Jain, Neelima Sinha et al. · European Journal of Medicinal Chemistry · 2004 · 197 citations

, , +8

Polymers of intrinsic microporosity (PIMs) substituted with methyl tetrazole

Naiying Du, Gilles P. Robertson, Mauro M. Dal‐Cin et al. · Polymer · 2012 · 106 citations · Full text

, , +13

Potent and Selective Non-Peptidic Inhibitors of Endothelin-Converting Enzyme-1 with Sustained Duration of Action

Stéphane De Lombaert, Louis Blanchard, Lisa B. Stamford et al. · Journal of Medicinal Chemistry · 2000 · 100 citations · Full text

, , +10

1–5 of 33

Authors

238

  1. RG
    Roy G. Smith

    Baylor College of Medicine, United States

    2 publications · 33 citations

    2

    h-index

  2. SD
    Salah D. Kivlighn

    United States Military Academy, United States

    2 publications · 40 citations

    2

    h-index

  3. MJ
    Matthew J. Wyvratt

    Merck & Co., Inc., Rahway, NJ, USA (United States), United States

    2 publications · 33 citations

    2

    h-index

  4. RS
    Raymond S.L. Chang

    United States Military Academy, United States

    2 publications · 40 citations

    2

    h-index

  5. RL
    Rodney L. Johnson

    University of Minnesota, United States

    2 publications · 41 citations

    2

    h-index

1–5 of 238

Institutions

51

  1. Merck & Co., Inc., Rahway, NJ, USA (United States)

    Rahway, United States

    4 h-index

    40 publications

    776 citations

  2. United States Military Academy

    West Point, United States

    2 h-index

    3 publications

    50 citations

  3. University of Minnesota

    Minneapolis, United States

    2 h-index

    3 publications

    59 citations

  4. Université de Montpellier

    Montpellier, France

    1 h-index

    3 publications

    60 citations

  5. Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry

    Prague, Czechia

    1 h-index

    2 publications

    46 citations

  6. Université Moulay Ismail de Meknes

    Meknes, Morocco

    1 h-index

    1 publications

    20 citations

  7. Centre National de la Recherche Scientifique

    Paris, France

    1 h-index

    3 publications

    60 citations

  8. Guilin Medical University

    Guilin, China

    1 h-index

    4 publications

    52 citations

1–8 of 51

Venues

  1. Journal of Medicinal Chemistry

    8 publications · 1.4K citations

    8

    h-index

  2. Bioorganic & Medicinal Chemistry Letters

    5 publications · 91 citations

    5

    h-index

  3. Chemistry of Heterocyclic Compounds

    2 publications · 42 citations

    2

    h-index

  4. 1

    h-index

  5. Journal of Inorganic Biochemistry

    1 publications · 13 citations

    1

    h-index

1–5