Concepedia

Tetrahedral Intermediates

Tetrahedral Intermediate is a transient reaction intermediate in organic chemistry characterized by a carbon center bonded to four substituents in a tetrahedral geometry, formed by nucleophilic addition to a carbonyl group, distinguishing it from planar carbonyl or other non-tetrahedral intermediates.

663

Publications

27.1K

Citations

2.1K

Authors

519

Institutions

Publications per year

2017–2026

43

Variants

Tetrahedral Intermediate

Parents

Publications

663

Transglutaminase 2 Undergoes a Large Conformational Change upon Activation

Daniel M. Pinkas, Pavel Strop, Axel T. Brünger et al. · PLoS Biology · 2007 · 445 citations · Full text

, , +16

Stabilization of Labile Carbonyl Addition Intermediates by a Synthetic Receptor

Tetsuo Iwasawa, Richard J. Hooley, Julius Rebek · Science · 2007 · 285 citations

, , +16

X-ray crystallographic structure of a complex between a synthetic protease of human immunodeficiency virus 1 and a substrate-based hydroxyethylamine inhibitor.

Amy L. Swain, Maria Miller, Jeremy Green et al. · Proceedings of the National Academy of Sciences · 1990 · 275 citations

, , +16

Synthesis, Morphology, and Optical Properties of Tetrahedral Oligo(phenylenevinylene) Materials

Shujun Wang, Warren J. Oldham, Raymond A. Hudack et al. · Journal of the American Chemical Society · 2000 · 266 citations

, , +13

Direct determination of the protonation states of aspartic acid-102 and histidine-57 in the tetrahedral intermediate of the serine proteases: neutron structure of trypsin

Anthony A. Kossiakoff, Steven A. Spencer · Biochemistry · 1981 · 266 citations

, , +17

1–5 of 663

Authors

2.1K

  1. IL
    Ikchoon Lee

    Inha University, South Korea

    12 publications · 535 citations

    12

    h-index

  2. MI
    Michael I. Page

    University of Huddersfield, United Kingdom

    13 publications · 328 citations

    11

    h-index

  3. EA
    Enrique A. Castro

    Pontificia Universidad Católica de Chile, Chile

    14 publications · 496 citations

    11

    h-index

  4. PD
    Pierre Deslongchamps

    Université de Sherbrooke, Canada

    12 publications · 589 citations

    11

    h-index

  5. JG
    José G. Santos

    Pontificia Universidad Católica de Chile, Chile

    11 publications · 303 citations

    10

    h-index

1–5 of 2.1K

Institutions

519

  1. Centre National de la Recherche Scientifique

    Paris, France

    13 h-index

    49 publications

    2.5K citations

  2. University of Wisconsin–Madison

    Madison, United States

    11 h-index

    45 publications

    1.7K citations

  3. University of California, Berkeley

    Berkeley, United States

    11 h-index

    33 publications

    1.6K citations

  4. Pontificia Universidad Católica de Chile

    Santiago, Chile

    11 h-index

    44 publications

    1.4K citations

  5. University of Oxford

    Oxford, United Kingdom

    8 h-index

    24 publications

    1.3K citations

  6. Université de Sherbrooke

    Sherbrooke, Canada

    7 h-index

    19 publications

    953 citations

  7. University of California, Santa Cruz

    Santa Cruz, United States

    7 h-index

    22 publications

    629 citations

  8. Scripps Research Institute

    San Diego, United States

    7 h-index

    28 publications

    2K citations

1–8 of 519

Venues

  1. Journal of the American Chemical Society

    JACS · 106 publications · 4.8K citations

    44

    h-index

  2. The Journal of Organic Chemistry

    JOC · 50 publications · 2.2K citations

    28

    h-index

  3. Biochemistry

    46 publications · 2.1K citations

    26

    h-index

  4. Inorganic Chemistry

    29 publications · 1K citations

    20

    h-index

  5. 16

    h-index

1–5