Concepedia

Termination Defects

Termination Defects is a molecular genetic phenomenon characterized by the failure of RNA polymerase to properly halt transcription at designated termination sites, leading to aberrant transcriptional readthrough and the production of extended or non-functional RNA transcripts.

50

Publications

2.8K

Citations

248

Authors

91

Institutions

Publications per year

2017–2026

16

Parents

Publications

50

Mammalian NET-Seq Reveals Genome-wide Nascent Transcription Coupled to RNA Processing

Takayuki Nojima, Tomás Gomes, Ana Rita Grosso et al. · Cell · 2015 · 604 citations · Full text

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Xrn2 accelerates termination by RNA polymerase II, which is underpinned by CPSF73 activity

Joshua D Eaton, Lee Davidson, David L.V. Bauer et al. · Genes & Development · 2018 · 144 citations · Full text

, , +17

Discrimination Between Defects in Elongation Fidelity and Termination Efficiency Provides Mechanistic Insights into Translational Readthrough

Joe Salas-Marco, David M. Bedwell · Journal of Molecular Biology · 2005 · 117 citations

, , +13

Mapping of transcription initiation and termination signals on Xenopus laevis ribosomal DNA.

A. Bakken, Gareth J. Morgan, Barbara Sollner-Webb et al. · Proceedings of the National Academy of Sciences · 1982 · 110 citations · Full text

, , +16

The Essential WD Repeat Protein Swd2 Has Dual Functions in RNA Polymerase II Transcription Termination and Lysine 4 Methylation of Histone H3

Hailing Cheng, Xiaoyuan He, Claire Moore · Molecular and Cellular Biology · 2004 · 104 citations · Full text

, , +17

1–5 of 50

Authors

248

  1. DL
    Domenico Libri

    Centre National de la Recherche Scientifique, France

    4 publications · 145 citations

    4

    h-index

  2. ME
    Max E. Gottesman

    Columbia University, United States

    2 publications · 99 citations

    2

    h-index

  3. SS
    Salam Shaaban

    University of Washington, United States

    2 publications · 75 citations

    2

    h-index

  4. DL
    Donald L. Court

    National Cancer Institute, United States

    2 publications · 42 citations

    2

    h-index

  5. TN
    T. Nicolai Siegel

    Ludwig-Maximilians-Universität München, Germany

    2 publications · 113 citations

    2

    h-index

1–5 of 248

Institutions

91

  1. University of Washington

    Seattle, United States

    4 h-index

    11 publications

    552 citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    3 h-index

    14 publications

    712 citations

  3. Université Paris Cité

    Paris, France

    3 h-index

    13 publications

    640 citations

  4. National Institutes of Health

    Bethesda, United States

    3 h-index

    11 publications

    598 citations

  5. Institut Jacques Monod

    Paris, France

    3 h-index

    13 publications

    640 citations

  6. Harvard University

    Cambridge, United States

    3 h-index

    6 publications

    279 citations

  7. National Cancer Institute

    Bethesda, United States

    2 h-index

    7 publications

    368 citations

  8. University of Alabama at Birmingham

    Birmingham, United States

    2 h-index

    8 publications

    354 citations

1–8 of 91

Venues

  1. Journal of Molecular Biology

    JMB · 6 publications · 330 citations

    6

    h-index

  2. Nucleic Acids Research

    5 publications · 240 citations

    5

    h-index

  3. Molecular and Cellular Biology

    MCB · 4 publications · 249 citations

    4

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 3 publications · 232 citations

    3

    h-index

  5. PLoS Genetics

    2 publications · 39 citations

    2

    h-index

1–5