Concepedia

Targeting Ligand Optimization

Targeting Ligand Optimization is a methodological framework in molecular imaging that systematically enhances the binding affinity, specificity, and pharmacokinetic properties of ligands to improve the efficacy of targeted imaging agents.

47

Publications

1.8K

Citations

399

Authors

145

Institutions

Publications per year

2017–2026

27

Parents

Publications

47

Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications

Carl C. Ward, Jordan I. Kleinman, Scott M. Brittain et al. · ACS Chemical Biology · 2019 · 336 citations · Full text

, , +16

Peptide targeted tripod macrocyclic Gd(III) chelates for cancer molecular MRI

Zhuxian Zhou, Xueming Wu, Adam Kresak et al. · Biomaterials · 2013 · 83 citations · Full text

, , +14

The Effect of Mini-PEG-Based Spacer Length on Binding and Pharmacokinetic Properties of a 68Ga-Labeled NOTA-Conjugated Antagonistic Analog of Bombesin

Zohreh Varasteh, Ulrika Rosenström, Irina Velikyan et al. · Molecules · 2014 · 78 citations · Full text

, , +17

Tumor-Targeting NHC–Au(I) Complex Induces Immunogenic Cell Death in Hepatocellular Carcinoma

Zhibin Yang, Mianli Bian, Lin Lv et al. · Journal of Medicinal Chemistry · 2023 · 62 citations

, , +14

Novel FAP ligands enable improved imaging contrast in sarcoma patients due to FAPI-PET/CT

Stefan A. Koerber, Rebecca Finck, Katharina Dendl et al. · European Journal of Nuclear Medicine and Molecular Imaging · 2021 · 60 citations · Full text

, , +15

1–5 of 47

Authors

399

  1. KH
    Kenneth H. Kim

    University of Alabama at Birmingham, United States

    2 publications · 360 citations

    2

    h-index

  2. DK
    Daniel K. Nomura

    University of California, Berkeley, United States

    2 publications · 360 citations

    2

    h-index

  3. PS
    Patrick S. Lee

    Novartis (United States), United States

    2 publications · 360 citations

    2

    h-index

  4. JM
    Jeffrey M. McKenna

    University of California, Berkeley, United States

    2 publications · 360 citations

    2

    h-index

  5. JA
    John A. Tallarico

    Novartis (United States), United States

    2 publications · 360 citations

    2

    h-index

1–5 of 399

Institutions

145

  1. Inserm

    Paris, France

    3 h-index

    19 publications

    329 citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    3 h-index

    22 publications

    327 citations

  3. National Institutes of Health

    Bethesda, United States

    2 h-index

    6 publications

    106 citations

  4. University of Pennsylvania

    Philadelphia, United States

    2 h-index

    14 publications

    270 citations

  5. Uppsala University

    Uppsala, Sweden

    2 h-index

    14 publications

    974 citations

  6. Vanderbilt University Medical Center

    Nashville, United States

    2 h-index

    8 publications

    239 citations

  7. Vanderbilt University

    Nashville, United States

    2 h-index

    16 publications

    595 citations

  8. Novartis (United States)

    New York, United States

    2 h-index

    7 publications

    2K citations

1–8 of 145

Venues

  1. Journal of Medicinal Chemistry

    9 publications · 316 citations

    9

    h-index

  2. Molecular Pharmaceutics

    2 publications · 66 citations

    2

    h-index

  3. Dalton Transactions

    2 publications · 52 citations

    2

    h-index

  4. Bioorganic & Medicinal Chemistry Letters

    2 publications · 51 citations

    2

    h-index

  5. Bioorganic & Medicinal Chemistry

    2 publications · 25 citations

    2

    h-index

1–5