Targeted Therapy Combinations is a therapeutic strategy that integrates multiple molecularly targeted agents to concurrently inhibit distinct oncogenic pathways or nodes within a single pathway, thereby enhancing anticancer efficacy while minimizing compensatory resistance mechanisms in the context of combination cancer and immunotherapy regimens.
206
Publications
10.2K
Citations
2K
Authors
707
Institutions
Publications per year
2017–2026
119
Variants
Combination Targeted Therapy
Publications
206
Evolutionary dynamics of cancer in response to targeted combination therapy
Ivana Božić, Johannes G. Reiter, Benjamin Allen et al. · eLife · 2013 · 647 citations · Full text
Medicine, Cancer Biology, Oncology +14
Effective combinatorial immunotherapy for castration-resistant prostate cancer
Xin Lü, James W. Horner, Erin Paul et al. · Nature · 2017 · 547 citations · Full text
Effective drug combinations in breast, colon and pancreatic cancer cells
Patricia Jaaks, Elizabeth A. Coker, Daniël J. Vis et al. · Nature · 2022 · 463 citations · Full text
Medicine, Oncology, Pharmacology +14
A combinatorial strategy for treating KRAS-mutant lung cancer
Eusebio Manchado, Susann Weissmueller, John P. Morris et al. · Nature · 2016 · 408 citations · Full text
Coexpression profile of leukemic stem cell markers for combinatorial targeted therapy in AML
Sascha Haubner, Fabiana Perna, Thomas Köhnke et al. · Leukemia · 2018 · 328 citations · Full text
Medicine, Hematology, Oncology +17
1–5 of 206
Authors
2K
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- KT
9
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- JAJennifer A. Wargo
The University of Texas MD Anderson Cancer Center, United States
7 publications · 171 citations
8
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- DP
8
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- GV
7
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1–5 of 2K
Institutions
707
The University of Texas MD Anderson Cancer Center
Houston, United States
17 h-index
165 publications
10.5K citations
Massachusetts General Hospital
Boston, United States
14 h-index
64 publications
4.9K citations
Harvard University
Cambridge, United States
14 h-index
86 publications
8.1K citations
Memorial Sloan Kettering Cancer Center
New York, United States
13 h-index
69 publications
9.7K citations
Dana-Farber Cancer Institute
Boston, United States
12 h-index
38 publications
2.6K citations
University of California, Los Angeles
Los Angeles, United States
11 h-index
32 publications
4.9K citations
The University of Sydney
Sydney, Australia
9 h-index
30 publications
1.4K citations
National Cancer Institute
Bethesda, United States
8 h-index
61 publications
4.2K citations
1–8 of 707
Venues
- Journal of Clinical Oncology
25 publications · 879 citations
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- Cancer Research
11 publications · 794 citations
11
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- Clinical Cancer Research
10 publications · 533 citations
11
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- Oncotarget
7 publications · 285 citations
7
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- PubMed
Repository · 7 publications · 257 citations
7
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