Concepedia

Target-site Diversification

Target-Site Diversification is a systematic method in molecular biology that introduces intentional sequence variation at specific genomic target sites to enhance the functional diversity of gene editing outcomes.

12

Publications

1K

Citations

88

Authors

42

Institutions

Publications per year

2017–2026

7

Parents

Publications

12

Targeted AID-mediated mutagenesis (TAM) enables efficient genomic diversification in mammalian cells

Yunqing Ma, Jiayuan Zhang, Weijie Yin et al. · Nature Methods · 2016 · 423 citations

, , +14

Human genetic diversity alters off-target outcomes of therapeutic gene editing

Samuele Cancellieri, Jing Zeng, Linda Yingqi Lin et al. · Nature Genetics · 2022 · 111 citations · Full text

, , +12

Improved specificity of TALE-based genome editing using an expanded RVD repertoire

Jeffrey C. Miller, Lei Zhang, Danny F. Xia et al. · Nature Methods · 2015 · 93 citations

, , +11

In vivo diversification of target genomic sites using processive base deaminase fusions blocked by dCas9

Beatriz Álvarez, Mario Mencı́a, Vı́ctor de Lorenzo et al. · Nature Communications · 2020 · 83 citations · Full text

, , +17

Spatiotemporal mapping of RNA editing in the developing mouse brain using in situ sequencing reveals regional and cell-type-specific regulation

Elin Lundin, Chenglin Wu, Albin Widmark et al. · BMC Biology · 2020 · 69 citations · Full text

, , +15

1–5 of 12

Authors

88

  1. JF
    Jeff F. Miller

    University of California, Los Angeles, United States

    2 publications · 84 citations

    2

    h-index

  2. LV
    Longping V. Tse

    University of North Carolina at Chapel Hill, United States

    2 publications · 84 citations

    2

    h-index

  3. HG
    Huatao Guo

    University of California, Los Angeles, United States

    2 publications · 84 citations

    2

    h-index

  4. XM
    Xiangdong Meng

    Sangamo BioSciences (United States), United States

    1 publications · 93 citations

    1

    h-index

  5. SJ
    Sarah J. Hinkley

    Sangamo BioSciences (United States), United States

    1 publications · 93 citations

    1

    h-index

1–5 of 88

Institutions

42

  1. University of California, Los Angeles

    Los Angeles, United States

    2 h-index

    14 publications

    588 citations

  2. Chinese Academy of Sciences

    Beijing, China

    2 h-index

    5 publications

    1.7K citations

  3. King Abdullah University of Science and Technology

    Jeddah, Saudi Arabia

    1 h-index

    1 publications

    12 citations

  4. Shanghai Center for Brain Science and Brain-Inspired Technology

    Shanghai, China

    1 h-index

    4 publications

    140 citations

  5. Lou Ruvo Brain Institute

    Las Vegas, United States

    1 h-index

    1 publications

    23 citations

  6. Zhongshan Hospital

    Shanghai, China

    1 h-index

    2 publications

    70 citations

  7. Max Planck Institute of Molecular Cell Biology and Genetics

    Dresden, Germany

    1 h-index

    1 publications

    45 citations

  8. AvidBiotics (United States)

    South San Francisco, United States

    1 h-index

    1 publications

    34 citations

1–8 of 42

Venues

  1. Nature Communications

    3 publications · 163 citations

    3

    h-index

  2. Nature Methods

    2 publications · 516 citations

    2

    h-index

  3. PLoS Genetics

    1 publications · 34 citations

    1

    h-index

  4. Journal of Neuropsychiatry

    JNCN · 1 publications · 23 citations

    1

    h-index

  5. Molecular Cell

    1 publications · 50 citations

    1

    h-index

1–5