Concepedia

Target-site Alteration

Target-Site Alteration is a genetic or structural modification in the molecular target of a biocide or inhibitor that reduces its binding affinity or functional interaction, thereby conferring resistance while maintaining the target's essential biological activity.

22

Publications

1.1K

Citations

109

Authors

52

Institutions

Publications per year

2017–2026

7

Parents

Publications

22

Sequence-specific modification of mitochondrial DNA using a chimeric zinc finger methylase

Michal Minczuk, Monika Papworth, Paulina Kolasinska et al. · Proceedings of the National Academy of Sciences · 2006 · 168 citations · Full text

, , +17

Monitoring of resistance to the pyrethroid cypermethrin in Brazilian Aedes aegypti (Diptera: Culicidae) populations collected between 2001 and 2003

Marcella Pereira da-Cunha, José Bento Pereira Lima, William G. Brogdon et al. · Memórias do Instituto Oswaldo Cruz · 2005 · 139 citations · Full text

, , +17

Satellite phage TLCφ enables toxigenic conversion by CTX phage through dif site alteration

Faizule Hassan, Muhammad Kamruzzaman, John J. Mekalanos et al. · Nature · 2010 · 108 citations

, , +5

Activation of cryptic aminoglycoside resistance in <i>Salmonella enterica</i>

Sanna Koskiniemi, Maria Pränting, Erik Gullberg et al. · Molecular Microbiology · 2011 · 106 citations · Full text

, , +17

Genetic Analysis of Streptomycin-Resistant (Sm<sup>R</sup>) Strains of <i>Erwinia amylovora</i> Suggests that Dissemination of Two Genotypes Is Responsible for the Current Distribution of Sm<sup>R</sup> <i>E. amylovora</i> in Michigan

Gayle C. McGhee, Jesse Guasco, Lisa M. Bellomo et al. · Phytopathology · 2010 · 83 citations

, , +17

1–5 of 22

Authors

109

  1. AK
    Aaron Klug

    MRC Laboratory of Molecular Biology, United Kingdom

    1 publications · 168 citations

    1

    h-index

  2. LB
    Leticia Barrientos

    Universidad de La Frontera, Chile

    1 publications · 17 citations

    1

    h-index

  3. MP
    Maria Pränting

    Uppsala University, Sweden

    1 publications · 106 citations

    1

    h-index

  4. CM
    Csaba Miskey

    Paul Ehrlich Institut, Germany

    1 publications · 27 citations

    1

    h-index

  5. SM
    Shah M. Faruque

    International Centre for Diarrhoeal Disease Research, Bangladesh

    1 publications · 108 citations

    1

    h-index

1–5 of 109

Institutions

52

  1. Harvard University

    Cambridge, United States

    3 h-index

    4 publications

    267 citations

  2. Liverpool School of Tropical Medicine

    Liverpool, United Kingdom

    2 h-index

    7 publications

    263 citations

  3. Hungarian Academy of Sciences

    Budapest, Hungary

    1 h-index

    1 publications

    27 citations

  4. Wageningen University & Research

    Wageningen, The Netherlands

    1 h-index

    1 publications

    17 citations

  5. Chonnam National University

    Gwangju, South Korea

    1 h-index

    1 publications

    32 citations

  6. Universitat de València

    Valencia, Spain

    1 h-index

    2 publications

    66 citations

  7. University of Zurich

    Zurich, Switzerland

    1 h-index

    1 publications

    27 citations

  8. University of Tennessee Health Science Center

    Memphis, United States

    1 h-index

    1 publications

    21 citations

1–8 of 52

Venues

  1. Scientific Reports

    2 publications · 47 citations

    2

    h-index

  2. Microorganisms

    1 publications · 17 citations

    1

    h-index

  3. Biochemical Journal

    BJ · 1 publications · 11 citations

    1

    h-index

  4. Nature

    1 publications · 108 citations

    1

    h-index

  5. Genetics

    1 publications · 21 citations

    1

    h-index

1–5