Concepedia

Tad Disruption

Tad Disruption is a computational method that identifies significant alterations in the three-dimensional organization of chromatin by detecting changes in the boundaries or interactions within Topologically Associating Domains across different biological conditions.

22

Publications

1.8K

Citations

1.4K

Authors

517

Institutions

Publications per year

2017–2026

22

Parents

Publications

22

Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer

Kadir C. Akdemir, Victoria T. Le, Sahaana Chandran et al. · Nature Genetics · 2020 · 308 citations · Full text

, , +17

HMGB2 Loss upon Senescence Entry Disrupts Genomic Organization and Induces CTCF Clustering across Cell Types

Anne Zirkel, Miloš Nikolić, Konstantinos Sofiadis et al. · Molecular Cell · 2018 · 241 citations · Full text

, , +15

Evolutionary stability of topologically associating domains is associated with conserved gene regulation

Jan Krefting, Miguel A. Andrade‐Navarro, Jonas Ibn-Salem · BMC Biology · 2018 · 176 citations · Full text

, , +17

How subtle changes in 3D structure can create large changes in transcription

Jordan Yupeng Xiao, Antonina Hafner, Alistair N. Boettiger · eLife · 2021 · 164 citations · Full text

, , +17

Topologically associating domain boundaries are required for normal genome function

Sudha Rajderkar, Iros Barozzi, Yiwen Zhu et al. · Communications Biology · 2023 · 152 citations · Full text

, , +17

1–5 of 22

Authors

1.4K

  1. OD
    Oliver Drechsel

    Centre for Genomic Regulation, Spain

    3 publications · 560 citations

    3

    h-index

  2. KR
    Karsten Rippe

    German Cancer Research Center, Germany

    4 publications · 868 citations

    3

    h-index

  3. EG
    Eduardo Gade Gusmao

    University of Cologne, Germany

    2 publications · 252 citations

    2

    h-index

  4. MN
    Miloš Nikolić

    University of Cologne, Germany

    2 publications · 252 citations

    2

    h-index

  5. RE
    Robert E. Hill

    Western General Hospital, United Kingdom

    2 publications · 161 citations

    2

    h-index

1–5 of 1.4K

Institutions

517

  1. University of Edinburgh

    Edinburgh, United Kingdom

    6 h-index

    24 publications

    2.7K citations

  2. Institute of Genetics and Cancer

    Edinburgh, United Kingdom

    4 h-index

    20 publications

    2.2K citations

  3. German Cancer Research Center

    Heidelberg, Germany

    3 h-index

    66 publications

    19.6K citations

  4. Broad Institute

    Cambridge, United States

    3 h-index

    85 publications

    25.4K citations

  5. University of Cologne

    Cologne, Germany

    3 h-index

    26 publications

    4.2K citations

  6. Stanford University

    Stanford, United States

    3 h-index

    12 publications

    2.4K citations

  7. University of California San Diego

    San Diego, United States

    3 h-index

    17 publications

    4.5K citations

  8. University of California, Davis

    Davis, United States

    3 h-index

    5 publications

    848 citations

1–8 of 517

Venues

  1. bioRxiv (Cold Spring Harbor Laboratory)

    Repository · 6 publications · 69 citations

    6

    h-index

  2. Development

    2 publications · 174 citations

    2

    h-index

  3. Communications Biology

    1 publications · 152 citations

    1

    h-index

  4. eLife

    1 publications · 164 citations

    1

    h-index

  5. F1000Research

    1 publications · 68 citations

    1

    h-index

1–5