Concepedia

Tac3 Mutations

TAC3 Mutations is a genetic alteration in the tachykinin 3 (TAC3) gene that disrupts neurokinin B signaling, leading to impaired hypothalamic-pituitary-gonadal axis activation and associated with congenital forms of hypogonadotropic hypogonadism within the study of puberty disorder genetics.

23

Publications

3K

Citations

156

Authors

70

Institutions

Publications per year

2017–2026

3

Variants

Tac3 Gene Mutations

Parents

Publications

23

TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction

A. Kemal Topaloğlu, Frank Reimann, Metin Güçlü et al. · Nature Genetics · 2008 · 956 citations · Full text

, , +17

Inactivating<i>KISS1</i>Mutation and Hypogonadotropic Hypogonadism

A. Kemal Topaloğlu, Javier A. Tello, Leman Damla Kotan et al. · New England Journal of Medicine · 2012 · 468 citations · Full text

, , +17

TAC3/TACR3 Mutations Reveal Preferential Activation of Gonadotropin-Releasing Hormone Release by Neurokinin B in Neonatal Life Followed by Reversal in Adulthood

Elena Gianetti, Cíntia Tusset, Sekoni D. Noel et al. · The Journal of Clinical Endocrinology & Metabolism · 2010 · 288 citations · Full text

, , +14

<i>TAC3</i>and<i>TACR3</i>Defects Cause Hypothalamic Congenital Hypogonadotropic Hypogonadism in Humans

Jacques Young, Jérôme Bouligand, Bruno Francou et al. · The Journal of Clinical Endocrinology & Metabolism · 2010 · 245 citations · Full text

, , +17

Kisspeptin Restores Pulsatile LH Secretion in Patients with Neurokinin B Signaling Deficiencies: Physiological, Pathophysiological and Therapeutic Implications

Jacques Young, Jyothis T. George, Javier A. Tello et al. · Neuroendocrinology · 2012 · 155 citations · Full text

, , +17

1–5 of 23

Authors

156

  1. AK
    A. Kemal Topaloğlu

    Cukurova University, Türkiye

    4 publications · 1.6K citations

    4

    h-index

  2. LD
    Leman Damla Kotan

    Cukurova University, Türkiye

    4 publications · 1.6K citations

    4

    h-index

  3. BF
    Bruno Francou

    Bicêtre Hospital, France

    3 publications · 500 citations

    3

    h-index

  4. MN
    Mehmet Nuri Özbek

    Cukurova University, Türkiye

    3 publications · 1.5K citations

    3

    h-index

  5. JY
    Jacques Young

    Bicêtre Hospital, France

    3 publications · 500 citations

    3

    h-index

1–5 of 156

Institutions

70

  1. Inserm

    Paris, France

    5 h-index

    27 publications

    4.3K citations

  2. Cukurova University

    Adana, Türkiye

    4 h-index

    24 publications

    9.3K citations

  3. Bicêtre Hospital

    Le Kremlin-Bicêtre, France

    3 h-index

    19 publications

    3.1K citations

  4. Université Paris Cité

    Paris, France

    3 h-index

    4 publications

    575 citations

  5. Assistance Publique – Hôpitaux de Paris

    Paris, France

    3 h-index

    15 publications

    2.4K citations

  6. Massachusetts General Hospital

    Boston, United States

    3 h-index

    12 publications

    2.6K citations

  7. Université Paris-Sud

    Orsay, France

    3 h-index

    22 publications

    3.6K citations

  8. Marmara University

    Istanbul, Türkiye

    2 h-index

    6 publications

    1.6K citations

1–8 of 70

Venues

  1. The Journal of Clinical Endocrinology & Metabolism

    JCEM · 3 publications · 668 citations

    3

    h-index

  2. PLoS ONE

    3 publications · 211 citations

    3

    h-index

  3. Hormone Research in Paediatrics

    2 publications · 36 citations

    2

    h-index

  4. General and Comparative Endocrinology

    1 publications · 10 citations

    1

    h-index

  5. International Scholarly Research Notices

    1 publications · 26 citations

    1

    h-index

1–5