Concepedia

Systemic Toxicity Thresholds

Systemic Toxicity Thresholds is a pharmacological metric that denotes the minimum plasma concentration of a local anesthetic at which adverse systemic effects, particularly on the central nervous system and cardiovascular system, are initiated in a susceptible individual.

46

Publications

2.2K

Citations

217

Authors

122

Institutions

Publications per year

2017–2026

9

Variants

Systemic Toxicity Threshold

Parents

Publications

46

Alterations in Central Nervous System Serotonergic and Dopaminergic Synaptic Activity in Adulthood after Prenatal or Neonatal Chlorpyrifos Exposure

Justin E Aldridge, Armando Meyer, Frederic J. Seidler et al. · Environmental Health Perspectives · 2005 · 180 citations · Full text

, , +17

Local and Systemic Toxicity of Intravitreal Melphalan for Vitreous Seeding in Retinoblastoma

Jasmine H. Francis, Paula Schaiquevich, Emiliano Buitrago et al. · Ophthalmology · 2014 · 175 citations · Full text

, , +14

Acute systemic toxicity—prospects for tiered testing strategies

Phil Botham · Toxicology in Vitro · 2003 · 129 citations

, , +13

Local anaesthetic systemic toxicity

Linsey Christie, John Picard, Guy Weinberg · BJA Education · 2014 · 120 citations · Full text

, , +6

Developmental Exposure of Rats to Chlorpyrifos Elicits Sex-Selective Hyperlipidemia and Hyperinsulinemia in Adulthood

Theodore A. Slotkin, Kathleen K. Brown, Frederic J. Seidler · Environmental Health Perspectives · 2005 · 96 citations · Full text

, , +17

1–5 of 46

Authors

217

  1. TA
    Theodore A. Slotkin

    Duke Medical Center, United States

    3 publications · 339 citations

    3

    h-index

  2. FJ
    Frederic J. Seidler

    Duke Medical Center, United States

    3 publications · 339 citations

    3

    h-index

  3. SL
    Silvia Lapenna

    Joint Research Centre, Italy

    2 publications · 96 citations

    2

    h-index

  4. JO
    J. Oscar Croxatto

    Universidad de Buenos Aires, Argentina

    2 publications · 228 citations

    2

    h-index

  5. MW
    Maurice Whelan

    Joint Research Centre, Italy

    2 publications · 68 citations

    2

    h-index

1–5 of 217

Institutions

122

  1. Fundação Oswaldo Cruz

    Rio de Janeiro, Brazil

    3 h-index

    7 publications

    411 citations

  2. Universidad de Buenos Aires

    Buenos Aires, Argentina

    3 h-index

    6 publications

    574 citations

  3. Escola Nacional de Saúde Pública

    Rio de Janeiro, Brazil

    3 h-index

    7 publications

    411 citations

  4. Garrahan Hospital

    Buenos Aires, Argentina

    2 h-index

    7 publications

    737 citations

  5. Duke Medical Center

    Durham, United States

    2 h-index

    6 publications

    912 citations

  6. Consejo Nacional de Investigaciones Científicas y Técnicas

    Buenos Aires, Argentina

    2 h-index

    4 publications

    456 citations

  7. Research Triangle Park Foundation

    Durham, United States

    2 h-index

    2 publications

    137 citations

  8. BASF (Germany)

    Ludwigshafen am Rhein, Germany

    2 h-index

    4 publications

    83 citations

1–8 of 122

Venues

  1. Toxicology and Applied Pharmacology

    TAAP · 4 publications · 144 citations

    4

    h-index

  2. Regulatory Toxicology and Pharmacology

    RTP · 4 publications · 112 citations

    4

    h-index

  3. Toxicology in Vitro

    3 publications · 154 citations

    3

    h-index

  4. Environmental Health Perspectives

    EHP · 3 publications · 339 citations

    3

    h-index

  5. Joint Research Centre (European Commission)

    Repository · 2 publications · 96 citations

    2

    h-index

1–5