Concepedia

Suz12 Function

SUZ12 Function is a molecular construct defining the role of the SUZ12 protein within the Polycomb Repressive Complex 2 (PRC2) as the critical subunit responsible for stabilizing complex integrity and enabling histone H3 lysine 27 trimethylation activity, thereby mediating epigenetic gene silencing.

70

Publications

6.2K

Citations

620

Authors

250

Institutions

Publications per year

2017–2026

38

Parents

Publications

70

Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity

Diego Pasini, Adrian P. Bracken, Michael Rugaard Jensen et al. · The EMBO Journal · 2004 · 905 citations · Full text

, , +14

SUZ12 Is Required for Both the Histone Methyltransferase Activity and the Silencing Function of the EED-EZH2 Complex

Ru Cao, Yi Zhang · Molecular Cell · 2004 · 803 citations · Full text

, , +16

Loss of miR-200 Inhibition of Suz12 Leads to Polycomb-Mediated Repression Required for the Formation and Maintenance of Cancer Stem Cells

Dimitrios Iliopoulos, Marianne Lindahl-Allen, Christos Polytarchou et al. · Molecular Cell · 2010 · 390 citations · Full text

, , +17

Accurate H3K27 methylation can be established de novo by SUZ12-directed PRC2

Jonas W. Højfeldt, Anne Laugesen, Berthe M. Willumsen et al. · Nature Structural & Molecular Biology · 2018 · 233 citations · Full text

, , +11

Structures of human PRC2 with its cofactors AEBP2 and JARID2

Vignesh Kasinath, Marco Faini, Simon Poepsel et al. · Science · 2018 · 201 citations · Full text

, , +17

1–5 of 70

Authors

620

  1. LJ
    Lorraine J. Gudas

    Cornell University, United States

    3 publications · 198 citations

    3

    h-index

  2. WS
    Warren S. Alexander

    Walter and Eliza Hall Institute of Medical Research, Australia

    3 publications · 250 citations

    3

    h-index

  3. AR
    Andrew R. Hoffman

    Stanford University, United States

    2 publications · 92 citations

    2

    h-index

  4. WT
    William T. Gibson

    University of British Columbia, Canada

    2 publications · 124 citations

    2

    h-index

  5. KH
    Kristian Helin

    University of Copenhagen, Denmark

    2 publications · 1.1K citations

    2

    h-index

1–5 of 620

Institutions

250

  1. Harvard University

    Cambridge, United States

    8 h-index

    35 publications

    3.7K citations

  2. Nanjing Medical University

    Nanjing, China

    5 h-index

    31 publications

    956 citations

  3. Inserm

    Paris, France

    4 h-index

    32 publications

    1.7K citations

  4. The University of Melbourne

    Melbourne, Australia

    4 h-index

    17 publications

    881 citations

  5. Brigham and Women's Hospital

    Boston, United States

    4 h-index

    20 publications

    1.8K citations

  6. University of Toronto

    Toronto, Canada

    4 h-index

    12 publications

    826 citations

  7. Centre National de la Recherche Scientifique

    Paris, France

    3 h-index

    23 publications

    1.2K citations

  8. Stanford University

    Stanford, United States

    3 h-index

    13 publications

    647 citations

1–8 of 250

Venues

  1. Nature Communications

    4 publications · 190 citations

    4

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 3 publications · 165 citations

    3

    h-index

  3. Molecular Cell

    3 publications · 1.4K citations

    3

    h-index

  4. Cancers

    2 publications · 31 citations

    2

    h-index

  5. Nucleic Acids Research

    2 publications · 102 citations

    2

    h-index

1–5