Concepedia

Supersaturation In Dissolution

Supersaturation in Dissolution is a pharmaceutical phenomenon wherein a dissolved drug concentration exceeds its equilibrium solubility in a given medium, temporarily existing in a metastable state that enhances apparent dissolution rates and bioavailability potential under specific formulation and environmental conditions.

42

Publications

1.8K

Citations

166

Authors

58

Institutions

Publications per year

2017–2026

22

Parents

Publications

42

Utility of Hydroxypropylmethylcellulose Acetate Succinate (HPMCAS) for Initiation and Maintenance of Drug Supersaturation in the GI Milieu

William Curatolo, James Nightingale, Scott M. Herbig · Pharmaceutical Research · 2009 · 300 citations

, , +14

Non-Sink Dissolution Conditions for Predicting Product Quality and In Vivo Performance of Supersaturating Drug Delivery Systems

Dajun Sun, Hong Wen, Lynne S. Taylor · Journal of Pharmaceutical Sciences · 2016 · 144 citations · Full text

, , +17

The effect of HPMCAS functional groups on drug crystallization from the supersaturated state and dissolution improvement

Keisuke Ueda, Kenjirou Higashi, Keiji Yamamoto et al. · International Journal of Pharmaceutics · 2014 · 127 citations

, , +15

Supersaturation–Nucleation Behavior of Poorly Soluble Drugs and its Impact on the Oral Absorption of Drugs in Thermodynamically High-Energy Forms

Shunsuke Ozaki, Takuma Minamisono, Taro Yamashita et al. · Journal of Pharmaceutical Sciences · 2011 · 80 citations

, , +17

Dissolution behavior of co-amorphous amino acid-indomethacin mixtures: The ability of amino acids to stabilize the supersaturated state of indomethacin

Rami Ojarinta, Aki T. Heikkinen, Elina Sievänen et al. · European Journal of Pharmaceutics and Biopharmaceutics · 2016 · 67 citations · Full text

, , +17

1–5 of 42

Authors

166

  1. LS
    Lynne S. Taylor

    Purdue University West Lafayette, United States

    5 publications · 308 citations

    5

    h-index

  2. KM
    Kunikazu Moribe

    Chiba University, Japan

    4 publications · 213 citations

    4

    h-index

  3. KH
    Kenjirou Higashi

    Chiba University, Japan

    4 publications · 213 citations

    4

    h-index

  4. KU
    Keisuke Ueda

    Chiba University, Japan

    4 publications · 213 citations

    4

    h-index

  5. KY
    Keiji Yamamoto

    Chiba University, Japan

    4 publications · 213 citations

    4

    h-index

1–5 of 166

Institutions

58

  1. Purdue University West Lafayette

    West Lafayette, United States

    6 h-index

    10 publications

    490 citations

  2. Universidade Federal de Santa Catarina

    Florianópolis, Brazil

    4 h-index

    15 publications

    303 citations

  3. The University of Texas at Austin

    Austin, United States

    4 h-index

    15 publications

    678 citations

  4. Chiba University

    Chiba, Japan

    4 h-index

    14 publications

    755 citations

  5. Setsunan University

    Osaka, Japan

    3 h-index

    7 publications

    253 citations

  6. Ritsumeikan University

    Kyoto, Japan

    2 h-index

    5 publications

    157 citations

  7. National and Kapodistrian University of Athens

    Athens, Greece

    2 h-index

    7 publications

    128 citations

  8. University of Copenhagen

    Copenhagen, Denmark

    2 h-index

    9 publications

    196 citations

1–8 of 58

Venues

  1. International Journal of Pharmaceutics

    7 publications · 311 citations

    7

    h-index

  2. European Journal of Pharmaceutical Sciences

    6 publications · 177 citations

    6

    h-index

  3. Molecular Pharmaceutics

    6 publications · 159 citations

    6

    h-index

  4. Journal of Pharmaceutical Sciences

    4 publications · 288 citations

    4

    h-index

  5. European Journal of Pharmaceutics and Biopharmaceutics

    EJPB · 3 publications · 133 citations

    3

    h-index

1–5