Inhibition of Crystal Nucleation and Growth by Water-Soluble Polymers and its Impact on the Supersaturation Profiles of Amorphous Drugs

Shunsuke Ozaki, Ikuo Kushida, Taro Yamashita, +3

Journal of Pharmaceutical Sciences

Water-soluble PolymersCrystal NucleationEngineeringSupersaturation ProfilesPolymer Science +5

Discovery of (1<i>R</i>,2<i>S</i>)-2-{[(2,4-Dimethylpyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)-<i>N</i>-(5-fluoropyridin-2-yl)cyclopropanecarboxamide (E2006): A Potent and Efficacious Oral Orexin Receptor Antagonist

Yu Yoshida, Yoshimitsu Naoe, Taro Terauchi, +10

Journal of Medicinal Chemistry

PharmacotherapyChemical BiologyExperimental PharmacologyPharmaceutical ChemistryMolecular Pharmacology +17

Supersaturation–Nucleation Behavior of Poorly Soluble Drugs and its Impact on the Oral Absorption of Drugs in Thermodynamically High-Energy Forms

Shunsuke Ozaki, Takuma Minamisono, Taro Yamashita, +2

Journal of Pharmaceutical Sciences

Thermodynamically High-energy FormsPharmaceutical ScienceEngineeringMedicinePhysical Chemistry +7

Solvent shift method for anti-precipitant screening of poorly soluble drugs using biorelevant medium and dimethyl sulfoxide

Taro Yamashita, Shunsuke Ozaki, Ikuo Kushida

International Journal of Pharmaceutics

Pharmaceutical ScienceDimethyl SulfoxidePharmaceutical ChemistryPreclinical Drug EvaluationBiochemistry +12

Selectivity on Ion Transport across Bilayer Lipid Membranes in the Presence of Gramicidin A

Shintaro Kubota, Shunsuke Ozaki, Jun Onishi, +2

Analytical Sciences

Ion TransportProteinlipid InteractionBiochemistryMembrane TransportLipids +6

Structure-based virtual screening for insect ecdysone receptor ligands using MM/PBSA

Shinri Horoiwa, Taiyo Yokoi, Satoru Masumoto, +7

Bioorganic & Medicinal Chemistry

BiochemistryNatural SciencesMolecular BiologyNon-peptide LigandChemical Probe +3

Evaluation of Drug Supersaturation by Thermodynamic and Kinetic Approaches for the Prediction of Oral Absorbability in Amorphous Pharmaceuticals

Shunsuke Ozaki, Ikuo Kushida, Taro Yamashita, +3

Journal of Pharmaceutical Sciences

EngineeringMedicineOral AbsorbabilityDrug PurityKinetic Approaches +10

The Interaction of Cyclic Naphthalene Diimide with G-Quadruplex under Molecular Crowding Condition

Tingting Zou, Shinobu Sato, Rui Yasukawa, +4

Molecules

Electrochemical elucidation on the mechanism of uncoupling caused by hydrophobic weak acids

Shunsuke Ozaki, Kenji Kano, Osamu Shirai

Physical Chemistry Chemical Physics

Assessment of species specificity of moulting accelerating compounds in Lepidoptera: comparison of activity between <i>Bombyx mori</i> and <i>Spodoptera littoralis</i> by <i>in vitro</i> reporter and <i>in vivo</i> toxicity assays

Thomas Soin, Ellen De Geyter, Hadi Mosallanejad, +16

Pest Management Science