Concepedia

Super-enhancer Looping

Super-Enhancer Looping is a chromatin architectural mechanism, within the broader class of DNA looping phenomena, that specifically involves the spatial clustering of multiple enhancer elements with target gene promoters via loop extrusion processes mediated by architectural proteins such as cohesin and CTCF, thereby amplifying transcriptional output in a cell-identity-specific manner.

10

Publications

2.2K

Citations

91

Authors

31

Institutions

Publications per year

2017–2026

6

Parents

Publications

10

Chromosomal loop anchorage of the kappa immunoglobulin gene occurs next to the enhancer in a region containing topoisomerase II sites

Peter N. Cockerill, William T. Garrard · Cell · 1986 · 901 citations

, , +10

Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus

Jian‐Feng Xiang, Qing-Fei Yin, Tian Chen et al. · Cell Research · 2014 · 737 citations · Full text

, , +17

CRISPR Reveals a Distal Super-Enhancer Required for Sox2 Expression in Mouse Embryonic Stem Cells

Yan Li, Chloe M. Rivera, Haruhiko Ishii et al. · PLoS ONE · 2014 · 221 citations · Full text

, , +17

CTCF-mediated chromatin looping provides a topological framework for the formation of phase-separated transcriptional condensates

Ryanggeun Lee, Moo-Koo Kang, Yong-Jin Kim et al. · Nucleic Acids Research · 2021 · 129 citations · Full text

, , +17

Oncogenic HOXB8 is driven by MYC-regulated super-enhancer and potentiates colorectal cancer invasiveness via BACH1

Ying Ying, Yejun Wang, Xiaoyan Huang et al. · Oncogene · 2019 · 75 citations

, , +16

1–5 of 10

Authors

91

  1. JG
    Junhui Ge

    Second Military Medical University, China

    1 publications · 737 citations

    1

    h-index

  2. HI
    Haruhiko Ishii

    University of California San Diego, United States

    1 publications · 221 citations

    1

    h-index

  3. AM
    Abheepsa Mishra

    The University of Texas Southwestern Medical Center, United States

    1 publications · 26 citations

    1

    h-index

  4. YD
    Yuichiro� Doki

    The University of Osaka, Japan

    1 publications · 28 citations

    1

    h-index

  5. YL
    Yan Li

    Xuzhou Medical College, China

    1 publications · 221 citations

    1

    h-index

1–5 of 91

Institutions

31

  1. Second Military Medical University

    Shanghai, China

    2 h-index

    6 publications

    2.3K citations

  2. The University of Texas Southwestern Medical Center

    Dallas, United States

    2 h-index

    8 publications

    1.1K citations

  3. Shenzhen University Health Science Center

    Shenzhen, China

    1 h-index

    11 publications

    825 citations

  4. Eastern Hepatobiliary Surgery Hospital

    Shanghai, China

    1 h-index

    3 publications

    63 citations

  5. Center for Excellence in Molecular Cell Science

    Shanghai, China

    1 h-index

    7 publications

    5.2K citations

  6. Ludwig Cancer Research

    New York, United States

    1 h-index

    8 publications

    1.8K citations

  7. Universitätsmedizin Göttingen

    Göttingen, Germany

    1 h-index

    5 publications

    140 citations

  8. Sichuan University

    Chengdu, China

    1 h-index

    1 publications

    75 citations

1–8 of 31

Venues

  1. Biochemical and Biophysical Research Communications

    BBRC · 2 publications · 64 citations

    2

    h-index

  2. Kidney International

    1 publications · 26 citations

    1

    h-index

  3. Breast Cancer Research

    BCR · 1 publications · 23 citations

    1

    h-index

  4. Cell Death and Differentiation

    CDD · 1 publications · 28 citations

    1

    h-index

  5. Nucleic Acids Research

    1 publications · 129 citations

    1

    h-index

1–5