Concepedia

Substrate-induced Stabilization

Substrate-Induced Stabilization is a biochemical phenomenon in enzyme stabilization wherein the binding of a substrate selectively enhances the conformational stability of an enzyme, thereby reducing its susceptibility to denaturation or inactivation under destabilizing conditions.

63

Publications

2.7K

Citations

291

Authors

138

Institutions

Publications per year

2017–2026

12

Parents

Publications

63

Insights into substrate stabilization from snapshots of the peptidyl transferase center of the intact 70S ribosome

R.M. Voorhees, Albert Weixlbaumer, David Loakes et al. · Nature Structural & Molecular Biology · 2009 · 367 citations · Full text

, , +16

Enzyme kinetics and substrate stabilization of detergent-solubilized and membraneous (Ca2+ + Mg2+)-activated ATPase from sarcoplasmic reticulum. Effect of protein-protein interactions.

Jesper V. Møller, K.E. Lind, Jens Peter Andersen · Journal of Biological Chemistry · 1980 · 242 citations · Full text

, , +17

Substrate-induced remodeling of the active site regulates human HTRA1 activity

Linda Truebestein, Annette Tennstaedt, Timon Mönig et al. · Nature Structural & Molecular Biology · 2011 · 132 citations

, , +10

Involvement of transporter recruitment as well as gene expression in the substrate-induced adaptive regulation of amino acid transport system A

Ruan Ling, Christy C. Bridges, Mitsuru Sugawara et al. · Biochimica et Biophysica Acta (BBA) - Biomembranes · 2001 · 106 citations

, , +13

Molecular basis for catalysis and substrate-mediated cellular stabilization of human tryptophan 2,3-dioxygenase

Ariel Lewis-Ballester, F. Forouhar, Sung-Mi Kim et al. · Scientific Reports · 2016 · 97 citations · Full text

, , +17

1–5 of 63

Authors

291

  1. AN
    Andrew Nelson

    University of Leeds, United Kingdom

    2 publications · 145 citations

    2

    h-index

  2. FA
    F. A. M. Leermakers

    Wageningen University & Research, Netherlands

    2 publications · 145 citations

    2

    h-index

  3. SS
    Subramanyam Swaminathan

    Brookhaven National Laboratory, United States

    1 publications · 60 citations

    1

    h-index

  4. CG
    Caroline Gabus

    École Normale Supérieure de Lyon, France

    1 publications · 28 citations

    1

    h-index

  5. TF
    Thomas F. Holzman

    Abbott (United States), United States

    1 publications · 19 citations

    1

    h-index

1–5 of 291

Institutions

138

  1. Plymouth Marine Laboratory

    Plymouth, United Kingdom

    2 h-index

    3 publications

    196 citations

  2. Graduate School Experimental Plant Sciences

    Wageningen, Netherlands

    2 h-index

    3 publications

    196 citations

  3. Board of the Swiss Federal Institutes of Technology

    Zurich, Switzerland

    2 h-index

    5 publications

    74 citations

  4. Centre National de la Recherche Scientifique

    Paris, France

    2 h-index

    4 publications

    148 citations

  5. Aarhus University

    Aarhus, Denmark

    2 h-index

    2 publications

    252 citations

  6. Columbia University

    New York, United States

    2 h-index

    7 publications

    505 citations

  7. The University of Tokyo

    Tokyo, Japan

    2 h-index

    3 publications

    52 citations

  8. University of Illinois Urbana-Champaign

    Urbana, United States

    2 h-index

    4 publications

    114 citations

1–8 of 138

Venues

  1. Journal of Biological Chemistry

    JBC · 11 publications · 550 citations

    11

    h-index

  2. Biochemistry

    4 publications · 118 citations

    4

    h-index

  3. The Journal of Physical Chemistry C

    3 publications · 125 citations

    3

    h-index

  4. Biochemical Journal

    BJ · 2 publications · 24 citations

    2

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 2 publications · 59 citations

    2

    h-index

1–5