Concepedia

Substrate Unfolding

Substrate Unfolding is a molecular process in which a cytosolic protein substrate undergoes conformational alteration to expose a pentapeptide motif recognized by chaperone proteins, enabling translocation across the lysosomal membrane during chaperone-mediated autophagy.

121

Publications

6.9K

Citations

635

Authors

222

Institutions

Publications per year

2017–2026

36

Parents

Publications

121

Global unfolding of a substrate protein by the Hsp100 chaperone ClpA

Eilika Weber‐Ban, Brian G. Reid, Andrew D. Miranker et al. · Nature · 1999 · 424 citations

, , +16

PARP-1 Activation Requires Local Unfolding of an Autoinhibitory Domain

Jennine M. Dawicki-McKenna, Marie-France Langelier, Jamie E. DeNizio et al. · Molecular Cell · 2015 · 353 citations · Full text

, , +8

Forced unfolding of fibronectin type 3 modules: an analysis by biased molecular dynamics simulations

Emanuele Paci, Martin Karplus · Journal of Molecular Biology · 1999 · 345 citations

, , +16

Forced unfolding of the fibronectin type III module reveals a tensile molecular recognition switch

André Krammer, Hui Lü, Barry Isralewitz et al. · Proceedings of the National Academy of Sciences · 1999 · 279 citations · Full text

, , +16

Hsp90 Mediates Membrane Deformation and Exosome Release

Elsa Lauwers, Yuchun Wang, Rodrigo Gallardo et al. · Molecular Cell · 2018 · 193 citations · Full text

, , +12

1–5 of 121

Authors

635

  1. TA
    Tania A. Baker

    Massachusetts Institute of Technology, United States

    6 publications · 215 citations

    6

    h-index

  2. RT
    Robert T. Sauer

    Massachusetts Institute of Technology, United States

    5 publications · 182 citations

    5

    h-index

  3. AM
    Axel Mogk

    Heidelberg University, Germany

    3 publications · 144 citations

    3

    h-index

  4. PC
    Philip Coffino

    University of California, San Francisco, United States

    3 publications · 152 citations

    3

    h-index

  5. WB
    Wolfgang Baumeister

    Max Planck Institute of Biochemistry, Germany

    3 publications · 387 citations

    3

    h-index

1–5 of 635

Institutions

222

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    11 h-index

    17 publications

    1.3K citations

  2. Massachusetts Institute of Technology

    Cambridge, United States

    8 h-index

    22 publications

    832 citations

  3. Harvard University

    Cambridge, United States

    8 h-index

    15 publications

    1.6K citations

  4. Max Planck Institute of Biochemistry

    Martinsried, Germany

    6 h-index

    25 publications

    3K citations

  5. University of Pennsylvania

    Philadelphia, United States

    4 h-index

    14 publications

    2.6K citations

  6. University of California, San Francisco

    San Francisco, United States

    4 h-index

    17 publications

    857 citations

  7. Centre National de la Recherche Scientifique

    Paris, France

    4 h-index

    11 publications

    445 citations

  8. University of Cambridge

    Cambridge, United Kingdom

    3 h-index

    8 publications

    858 citations

1–8 of 222

Venues

  1. Journal of Biological Chemistry

    JBC · 21 publications · 958 citations

    18

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 11 publications · 1.2K citations

    11

    h-index

  3. Nature Communications

    6 publications · 444 citations

    6

    h-index

  4. eLife

    5 publications · 209 citations

    5

    h-index

  5. Biochemistry

    5 publications · 128 citations

    5

    h-index

1–5