Concepedia

Substrate Transition State Complementarity

Substrate Transition State Complementarity is a biochemical principle within enzyme catalysis wherein the active site of an enzyme exhibits a structural and electronic complementarity to the transition state of the substrate, thereby stabilizing it more effectively than the ground state and accelerating the reaction rate.

5

Publications

630

Citations

17

Authors

6

Institutions

Publications per year

2017–2026

0

Parents

Publications

5

Why Enzymes Are Proficient Catalysts:  Beyond the Pauling Paradigm

Xiyun Zhang, K. N. Houk · Accounts of Chemical Research · 2005 · 304 citations

, , +17

Catalysis, binding and enzyme-substrate complementarity

Alan R. Fersht · Proceedings of the Royal Society of London. Series B, Biological sciences · 1974 · 230 citations

, , +17

Impaired Transition State Complementarity in the Hydrolysis of <i>O</i>-Arylphosphorothioates by Protein-Tyrosine Phosphatases

Yanling Zhang, Florian Hollfelder, Steven J. Gordon et al. · Biochemistry · 1999 · 60 citations

, , +16

Why Enzymes Are Proficient Catalysts: Beyond the Pauling Paradigm

Xiyun Zhang, K. N. Houk · ChemInform · 2005 · 19 citations · Full text

, , +17

A Kinetic Study of the Conjugate Addition of Benzenethiol to Cyclic Enones Catalyzed by a Nonsymmetrical Uranyl−Salophen Complex

Valeria Castelli, Antonella Dalla Cort, Luigi Mandolini et al. · The Journal of Organic Chemistry · 2007 · 17 citations

, , +14

1–5 of 5

Authors

17

  1. XZ
    Xiyun Zhang

    East China Normal University, China

    2 publications · 323 citations

    2

    h-index

  2. YZ
    Yanling Zhang

    University of Science and Technology Beijing, China

    1 publications · 60 citations

    1

    h-index

  3. KN
    K. N. Houk

    University of California, Los Angeles, United States

    1 publications · 19 citations

    1

    h-index

  4. KN
    K. N. Houk

    University of California, Los Angeles, United States

    1 publications · 304 citations

    1

    h-index

  5. LS
    Luca Schiaffino

    Sapienza University of Rome, Italy

    1 publications · 17 citations

    1

    h-index

1–5 of 17

Institutions

6

  1. University of Cambridge

    Cambridge, United Kingdom

    1 h-index

    8 publications

    480 citations

  2. University of California, Los Angeles

    Los Angeles, United States

    1 h-index

    2 publications

    608 citations

  3. MRC Laboratory of Molecular Biology

    Cambridge, United Kingdom

    1 h-index

    1 publications

    230 citations

  4. Sapienza University of Rome

    Rome, Italy

    1 h-index

    5 publications

    85 citations

  5. Stanford University

    Stanford, United States

    1 h-index

    8 publications

    480 citations

  6. Albert Einstein College of Medicine

    Bronx, United States

    1 h-index

    8 publications

    480 citations

1–6 of 6

Venues

  1. Biochemistry

    1 publications · 60 citations

    1

    h-index

  2. 1

    h-index

  3. Accounts of Chemical Research

    1 publications · 304 citations

    1

    h-index

  4. ChemInform

    1 publications · 19 citations

    1

    h-index

  5. The Journal of Organic Chemistry

    JOC · 1 publications · 17 citations

    1

    h-index

1–5