Concepedia

Substrate Promiscuity

Substrate Promiscuity is a biochemical phenomenon in which an enzyme exhibits the capacity to bind and catalyze reactions for multiple structurally distinct substrates, thereby deviating from strict substrate specificity in the context of induced fit and substrate binding.

315

Publications

13.5K

Citations

1.7K

Authors

511

Institutions

Publications per year

2017–2026

160

Parents

Publications

315

The Processivity of Multiubiquitination by the APC Determines the Order of Substrate Degradation

Michael Rapé, Sashank Reddy, Marc W. Kirschner · Cell · 2006 · 279 citations · Full text

, , +11

Hyperstability and Substrate Promiscuity in Laboratory Resurrections of Precambrian β-Lactamases

Valeria A. Risso, Diego F. Mejia-Carmona, Eric A. Gaucher et al. · Journal of the American Chemical Society · 2013 · 262 citations · Full text

, , +17

Structural and Chemical Profiling of the Human Cytosolic Sulfotransferases

Abdellah Allali‐Hassani, Patricia W. Pan, L. Dombrovski et al. · PLoS Biology · 2007 · 221 citations · Full text

, , +17

Mechanistic insight into digoxin inactivation by<i>Eggerthella lenta</i>augments our understanding of its pharmacokinetics

Henry J. Haiser, Kristen L. Seim, Emily P. Balskus et al. · Gut Microbes · 2014 · 183 citations · Full text

, , +16

Substrate specificity and some other properties of baker's yeast hexokinase

Alberto Sols Gertrudis De la Fuente, C. Villar‐Palasi, Carlos Asensio · Biochimica et Biophysica Acta · 1958 · 180 citations

, , +15

1–5 of 315

Authors

1.7K

  1. SL
    Shu‐Ming Li

    Philipps University of Marburg, Germany

    8 publications · 249 citations

    8

    h-index

  2. MF
    Manuel Ferrer

    Instituto de Catálisis y Petroleoquímica, Spain

    7 publications · 307 citations

    7

    h-index

  3. XC
    Xi Chen

    University of California, Davis, United States

    7 publications · 277 citations

    7

    h-index

  4. HY
    Hai Yu

    University of California, Davis, United States

    7 publications · 277 citations

    7

    h-index

  5. CC
    Cristina Coscolín

    Consejo Superior de Investigaciones Científicas, Spain

    5 publications · 237 citations

    5

    h-index

1–5 of 1.7K

Institutions

511

  1. Chinese Academy of Sciences

    Beijing, China

    16 h-index

    85 publications

    3.1K citations

  2. Chinese Academy of Medical Sciences & Peking Union Medical College

    Beijing, China

    11 h-index

    83 publications

    4.3K citations

  3. Consejo Superior de Investigaciones Científicas

    Madrid, Spain

    10 h-index

    35 publications

    2.1K citations

  4. Philipps University of Marburg

    Marburg, Germany

    10 h-index

    28 publications

    1K citations

  5. University of California, Davis

    Davis, United States

    9 h-index

    67 publications

    2.6K citations

  6. University of Chinese Academy of Sciences

    Beijing, China

    9 h-index

    36 publications

    1.1K citations

  7. Harvard University

    Cambridge, United States

    8 h-index

    27 publications

    2.6K citations

  8. Zhejiang University

    Hangzhou, China

    8 h-index

    24 publications

    650 citations

1–8 of 511

Venues

  1. ACS Catalysis

    17 publications · 553 citations

    17

    h-index

  2. ChemBioChem

    18 publications · 854 citations

    15

    h-index

  3. Journal of the American Chemical Society

    JACS · 16 publications · 1.1K citations

    15

    h-index

  4. ACS Chemical Biology

    13 publications · 598 citations

    13

    h-index

  5. Biochemistry

    12 publications · 445 citations

    11

    h-index

1–5