Valeria A. Risso

Hyperstability and Substrate Promiscuity in Laboratory Resurrections of Precambrian β-Lactamases

Valeria A. Risso, Diego F. Mejia-Carmona, Eric A. Gaucher et al. · Journal of the American Chemical Society · 2013 · 254 citations · Full text

Biochemistry, Protein Folding, Sequence Reconstruction Analysis +15

Evolution of Conformational Dynamics Determines the Conversion of a Promiscuous Generalist into a Specialist Enzyme

Tangbin Zou, Valeria A. Risso, José M. Sánchez‐Ruiz et al. · Molecular Biology and Evolution · 2014 · 149 citations · Full text

Conformational Dynamics, Molecular Biology, Analytical Ultracentrifugation +16

Mutational Studies on Resurrected Ancestral Proteins Reveal Conservation of Site-Specific Amino Acid Preferences throughout Evolutionary History

Valeria A. Risso, Fadia Manssour-Triedo, Asunción Delgado-Delgado et al. · Molecular Biology and Evolution · 2014 · 90 citations · Full text

Genetics, Molecular Biology, Molecular Genetics +21

De novo active sites for resurrected Precambrian enzymes

Valeria A. Risso, Sergio Martínez‐Rodríguez, Adela M. Candel et al. · Nature Communications · 2017 · 82 citations · Full text

Hinge-shift mechanism as a protein design principle for the evolution of β-lactamases from substrate promiscuity to specificity

Tushar Modi, Valeria A. Risso, Sergio Martínez‐Rodríguez et al. · Nature Communications · 2021 · 68 citations · Full text