Concepedia

Substitution Mutagenesis

Substitution Mutagenesis is a site-directed mutagenesis technique that involves the targeted replacement of a specific nucleotide or amino acid with another to investigate the functional impact of single molecular substitutions.

306

Publications

25.4K

Citations

1.2K

Authors

392

Institutions

Publications per year

2017–2026

11

Parents

Publications

306

Rapid and efficient site-specific mutagenesis without phenotypic selection.

Thomas A. Kunkel · Proceedings of the National Academy of Sciences · 1985 · 7.3K citations · Full text

, , +15

Molecular basis of base substitution hotspots in Escherichia coli

Christine Coulondre, Jeffrey H Miller, Philip J. Farabaugh et al. · Nature · 1978 · 1.2K citations

, , +10

Tuning the activity of an enzyme for unusual environments: sequential random mutagenesis of subtilisin E for catalysis in dimethylformamide.

Kun Chen, Frances H. Arnold · Proceedings of the National Academy of Sciences · 1993 · 541 citations

, , +16

Mutagen testing using TRP+ reversion in Escherichia coli

M.H.L. Green, W.J. Muriel · Mutation Research/Environmental Mutagenesis and Related Subjects · 1976 · 440 citations

, , +8

Suggestions for “safe” residue substitutions in site-directed mutagenesis

Domenico Bordo, Patrick Argos · Journal of Molecular Biology · 1991 · 384 citations

, , +9

1–5 of 306

Authors

1.2K

  1. EL
    Edward L. Loechler

    Boston University, United States

    5 publications · 189 citations

    5

    h-index

  2. RE
    Richard E. Hauhart

    Washington University in St. Louis, United States

    4 publications · 261 citations

    4

    h-index

  3. TA
    Thomas A. Kunkel

    National Institute of Environmental Health Sciences, United States

    4 publications · 7.4K citations

    4

    h-index

  4. EP
    Etana Padan

    Hebrew University of Jerusalem, Israel

    3 publications · 160 citations

    3

    h-index

  5. HR
    H. Ronald Kaback

    University of California, Los Angeles, United States

    3 publications · 164 citations

    3

    h-index

1–5 of 1.2K

Institutions

392

  1. Harvard University

    Cambridge, United States

    10 h-index

    17 publications

    3.1K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    8 h-index

    26 publications

    909 citations

  3. New York University

    New York, United States

    8 h-index

    20 publications

    1.7K citations

  4. Johns Hopkins University

    Baltimore, United States

    7 h-index

    10 publications

    847 citations

  5. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    6 h-index

    17 publications

    974 citations

  6. Boston University

    Boston, United States

    6 h-index

    13 publications

    521 citations

  7. University of Pennsylvania

    Philadelphia, United States

    5 h-index

    13 publications

    532 citations

  8. National Institutes of Health

    Bethesda, United States

    5 h-index

    18 publications

    506 citations

1–8 of 392

Venues

  1. Journal of Biological Chemistry

    JBC · 62 publications · 3.7K citations

    40

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 16 publications · 8.9K citations

    16

    h-index

  3. Biochemistry

    17 publications · 856 citations

    16

    h-index

  4. Nucleic Acids Research

    18 publications · 884 citations

    15

    h-index

  5. Journal of Bacteriology

    JB · 12 publications · 556 citations

    11

    h-index

1–5