Concepedia

Substituent Effects

Substituent Effects is a physical-organic and structure–activity relationship concept denoting the systematic influence that the nature, position, and properties of substituents exert on a molecule’s electronic distribution, steric environment, and other physicochemical parameters, thereby modulating its reactivity and/or biological activity relative to an unsubstituted or differently substituted reference scaffold.

5.4K

Publications

220.7K

Citations

12K

Authors

1.5K

Institutions

Publications per year

2017–2026

178

Variants

Substituent Effect

Parents

Children

Publications

5.4K

The Effect of Structure upon the Reactions of Organic Compounds. Benzene Derivatives

Louis P. Hammett · Journal of the American Chemical Society · 1937 · 2.2K citations

, , +10

Predicting the Activity of Phenolic Antioxidants:  Theoretical Method, Analysis of Substituent Effects, and Application to Major Families of Antioxidants

James S. Wright, Erin R. Johnson, Gino A. DiLabio · Journal of the American Chemical Society · 2001 · 1.6K citations

, , +15

An index of substitution saturation and its application

Xuhua Xia, Zheng Xie, Marco Salemi et al. · Molecular Phylogenetics and Evolution · 2002 · 1.5K citations

, , +4

Fluorine substituent effects (on bioactivity)

Bruce E. Smart · Journal of Fluorine Chemistry · 2001 · 1.5K citations

, , +4

Aromatic substituent constants for structure-activity correlations

Corwin Hansch, Albert J. Leo, Stefan Unger et al. · Journal of Medicinal Chemistry · 1973 · 1.3K citations

, , +14

1–5 of 5.4K

Authors

12K

  1. HC
    Herbert C. Brown

    Purdue University West Lafayette, United States

    63 publications · 4.6K citations

    29

    h-index

  2. KN
    K. N. Houk

    University of California, Los Angeles, United States

    29 publications · 2.2K citations

    25

    h-index

  3. SW
    S. Winstein

    University of California, Los Angeles, United States

    27 publications · 1.3K citations

    21

    h-index

  4. TM
    Tadeusz M. Krygowski

    University of Warsaw, Poland

    33 publications · 1K citations

    20

    h-index

  5. OE
    Otto Exner

    Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry, Czechia

    36 publications · 1.2K citations

    20

    h-index

1–5 of 12K

Institutions

1.5K

  1. Centre National de la Recherche Scientifique

    Paris, France

    25 h-index

    150 publications

    5.3K citations

  2. The University of Osaka

    Osaka, Japan

    21 h-index

    99 publications

    4.4K citations

  3. University of California, Los Angeles

    Los Angeles, United States

    20 h-index

    69 publications

    6K citations

  4. Kyoto University

    Kyoto, Japan

    19 h-index

    96 publications

    3.6K citations

  5. University of Warsaw

    Warsaw, Poland

    18 h-index

    55 publications

    1.7K citations

  6. Universidad Autónoma de Madrid

    Madrid, Spain

    16 h-index

    57 publications

    1.7K citations

  7. Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry

    Prague, Czechia

    16 h-index

    41 publications

    1.2K citations

  8. Kyushu University

    Fukuoka, Japan

    16 h-index

    82 publications

    2.4K citations

1–8 of 1.5K

Venues

  1. Journal of the American Chemical Society

    JACS · 1.6K publications · 81.3K citations

    118

    h-index

  2. The Journal of Organic Chemistry

    JOC · 1K publications · 34.8K citations

    76

    h-index

  3. The Journal of Physical Chemistry

    198 publications · 9.5K citations

    51

    h-index

  4. Inorganic Chemistry

    99 publications · 3.8K citations

    36

    h-index

  5. Organometallics

    60 publications · 2.7K citations

    32

    h-index

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