Substituent Constants is a quantitative metric in physical organic chemistry that characterizes the electronic influence of a substituent group on the reactivity of a molecular scaffold by measuring its ability to donate or withdraw electron density relative to hydrogen.
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Aromatic substituent constants for structure-activity correlations
Corwin Hansch, Albert J. Leo, Stefan Unger et al. · Journal of Medicinal Chemistry · 1973 · 1.3K citations
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Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry, Czechia
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University of Warsaw
Warsaw, Poland
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University of Pardubice
Pardubice, Czechia
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Osaka City University
Osaka, Japan
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University of Basel
Basel, Switzerland
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Kyoto University
Kyoto, Japan
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The University of Osaka
Osaka, Japan
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Pomona College
Claremont, United States
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Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry
Prague, Czechia
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