Concepedia

Structure-based Pharmacophore Refinement

Structure-Based Pharmacophore Refinement is a computational method in drug design that refines pharmacophore models by incorporating three-dimensional structural information of target macromolecules to enhance the accuracy and predictive power of ligand-receptor interactions.

112

Publications

3.6K

Citations

734

Authors

235

Institutions

Publications per year

2017–2026

33

Parents

Publications

112

Refinement and Evaluation of a Pharmacophore Model for Flavone Derivatives Binding to the Benzodiazepine Site of the GABA<sub>A</sub> Receptor

Pia Kahnberg, Erik Lager, Celia Rosenberg et al. · Journal of Medicinal Chemistry · 2002 · 130 citations

, , +17

Molecular Modeling of the Three-Dimensional Structure of Dopamine 3 (D<sub>3</sub>) Subtype Receptor:  Discovery of Novel and Potent D<sub>3</sub>Ligands through a Hybrid Pharmacophore- and Structure-Based Database Searching Approach

Judith Varady, Xihan Wu, Xueliang Fang et al. · Journal of Medicinal Chemistry · 2003 · 128 citations · Full text

, , +17

Synthesis, biological evaluation and 3D-QSAR studies of 3-keto salicylic acid chalcones and related amides as novel HIV-1 integrase inhibitors

Horrick Sharma, Shivaputra A. Patil, Tino W. Sanchez et al. · Bioorganic & Medicinal Chemistry · 2011 · 110 citations · Full text

, , +17

Discovery and optimization of a series of quinazolinone-derived antagonists of CXCR3

Michael G. Johnson, An‐Rong Li, Jiwen Liu et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 105 citations · Full text

, , +12

A Three-Dimensional Pharmacophore Model for 5-Hydroxytryptamine<sub>6</sub>(5-HT<sub>6</sub>) Receptor Antagonists

María L. López-Rodrı́guez, Bellinda Benhamú, T. de la Fuente et al. · Journal of Medicinal Chemistry · 2005 · 89 citations · Full text

, , +17

1–5 of 112

Authors

734

  1. KW
    Keun Woo Lee

    Gyeongsang National University, South Korea

    3 publications · 101 citations

    3

    h-index

  2. MC
    Mukesh C. Sharma

    Devi Ahilya Vishwavidyalaya, India

    2 publications · 33 citations

    2

    h-index

  3. AS
    Achintya Saha

    University of Calcutta, India

    2 publications · 32 citations

    2

    h-index

  4. SP
    Sivakumar Prasanth Kumar

    Gujarat University, India

    2 publications · 34 citations

    2

    h-index

  5. SL
    Shuai Lü

    China Pharmaceutical University, China

    2 publications · 38 citations

    2

    h-index

1–5 of 734

Institutions

235

  1. China Pharmaceutical University

    Nanjing, China

    5 h-index

    28 publications

    787 citations

  2. National Institutes of Health

    Bethesda, United States

    3 h-index

    13 publications

    481 citations

  3. University of Michigan

    Ann Arbor, United States

    3 h-index

    11 publications

    1K citations

  4. Gyeongsang National University

    Jinju-si, South Korea

    3 h-index

    21 publications

    675 citations

  5. University of Ferrara

    Ferrara, Italy

    2 h-index

    6 publications

    129 citations

  6. Devi Ahilya Vishwavidyalaya

    Indore, India

    2 h-index

    6 publications

    99 citations

  7. University of Calcutta

    Kolkata, India

    2 h-index

    6 publications

    80 citations

  8. University of Genoa

    Genoa, Italy

    2 h-index

    5 publications

    119 citations

1–8 of 235

Venues

  1. Journal of Medicinal Chemistry

    10 publications · 591 citations

    10

    h-index

  2. Bioorganic & Medicinal Chemistry

    10 publications · 380 citations

    10

    h-index

  3. Bioorganic & Medicinal Chemistry Letters

    10 publications · 269 citations

    10

    h-index

  4. European Journal of Medicinal Chemistry

    9 publications · 207 citations

    9

    h-index

  5. Journal of Chemical Information and Modeling

    JCIM · 6 publications · 186 citations

    6

    h-index

1–5