Concepedia

Starting Dose Determination

Starting Dose Determination is a methodological framework in pharmacological and clinical research that specifies the initial dosage of a therapeutic agent to be administered in a study, distinguished by its reliance on preclinical data, safety profiles, and pharmacokinetic-pharmacodynamic modeling to ensure both efficacy and patient safety.

127

Publications

6.9K

Citations

816

Authors

375

Institutions

Publications per year

2017–2026

29

Parents

Publications

127

Ixekizumab, an interleukin-17A specific monoclonal antibody, for the treatment of biologic-naive patients with active psoriatic arthritis: results from the 24-week randomised, double-blind, placebo-controlled and active (adalimumab)-controlled period of the phase III trial SPIRIT-P1

Philip J. Mease, Désirée van der Heijde, Masato Okada et al. · Annals of the Rheumatic Diseases · 2016 · 568 citations · Full text

, , +15

Dose translation between laboratory animals and human in preclinical and clinical phases of drug development

Anroop B. Nair, Mohamed A. Morsy, Shery Jacob · Drug Development Research · 2018 · 457 citations

, , +16

How to calculate the dose of chemotherapy

Howard Gurney · British Journal of Cancer · 2002 · 253 citations · Full text

, , +17

Interpretation of Animal Dose and Human Equivalent Dose for Drug Development

Jang‐Woo Shin, In-Chan Seol, Chang‐Gue Son · 2010 · 244 citations

, , +15

A multicenter, Phase II trial of weekly irinotecan (CPT-11) in patients with previously treated colorectal carcinoma

Mace L. Rothenberg, John V. Cox, Russell F. DeVore et al. · Cancer · 1999 · 200 citations

, , +14

1–5 of 127

Authors

816

  1. DA
    Dennis A. Hesselink

    Erasmus MC, Netherlands

    2 publications · 172 citations

    2

    h-index

  2. TV
    Teun van Gelder

    Erasmus MC, Netherlands

    2 publications · 172 citations

    2

    h-index

  3. AD
    Anthonius de Boer

    Utrecht University, Netherlands

    2 publications · 121 citations

    2

    h-index

  4. AB
    Anroop B. Nair

    King Faisal University, Saudi Arabia

    2 publications · 548 citations

    2

    h-index

  5. LM
    Louise M. Andrews

    Erasmus MC, Netherlands

    2 publications · 172 citations

    2

    h-index

1–5 of 816

Institutions

375

  1. Center for Drug Evaluation and Research

    Silver Spring, United States

    6 h-index

    13 publications

    789 citations

  2. Leiden University Medical Center

    Leiden, The Netherlands

    5 h-index

    9 publications

    1.3K citations

  3. Utrecht University

    Utrecht, The Netherlands

    4 h-index

    14 publications

    699 citations

  4. Erasmus MC

    Rotterdam, The Netherlands

    4 h-index

    16 publications

    1.1K citations

  5. Roche (Switzerland)

    Basel, Switzerland

    4 h-index

    14 publications

    409 citations

  6. Eli Lilly (United States)

    Indianapolis, United States

    4 h-index

    19 publications

    4.2K citations

  7. University of Washington

    Seattle, United States

    3 h-index

    3 publications

    174 citations

  8. University of Pennsylvania

    Philadelphia, United States

    3 h-index

    21 publications

    1.6K citations

1–8 of 375

Venues

  1. PubMed

    Repository · 13 publications · 567 citations

    12

    h-index

  2. Clinical Pharmacology & Therapeutics

    CPT · 4 publications · 227 citations

    4

    h-index

  3. Cancer Chemotherapy and Pharmacology

    4 publications · 277 citations

    4

    h-index

  4. The Journal of Clinical Pharmacology

    4 publications · 180 citations

    4

    h-index

  5. British Journal of Clinical Pharmacology

    BJCP · 3 publications · 136 citations

    3

    h-index

1–5