Concepedia

Stability-activity Trade-off

Stability-Activity Trade-Off is a theoretical construct in enzyme evolution that characterizes the inverse relationship between an enzyme's structural stability and its catalytic activity, where enhancements in one property often lead to compromises in the other.

32

Publications

2.2K

Citations

180

Authors

87

Institutions

Publications per year

2017–2026

24

Parents

Publications

32

Glycoforms modify the dynamic stability and functional activity of an enzyme

Pauline M. Rudd, Heidi C. João, E. Coghill et al. · Biochemistry · 1994 · 295 citations

, , +12

Stability-activity tradeoffs constrain the adaptive evolution of RubisCO

Romain A. Studer, Pascal‐Antoine Christin, Mark A. Williams et al. · Proceedings of the National Academy of Sciences · 2014 · 191 citations · Full text

, , +17

Nano-island-encapsulated cobalt single-atom catalysts for breaking activity-stability trade-off in Fenton-like reactions

Zhiquan Zhang, Pijun Duan, Jiexuan Zheng et al. · Nature Communications · 2025 · 170 citations · Full text

, , +16

Recent advances in Ru-based electrocatalysts for oxygen evolution reaction

Jie Ying, Jiangbo Chen, Yuxuan Xiao et al. · Journal of Materials Chemistry A · 2022 · 160 citations · Full text

, , +17

Exploiting correlated molecular-dynamics networks to counteract enzyme activity–stability trade-off

Haoran Yu, Paul A. Dalby · Proceedings of the National Academy of Sciences · 2018 · 128 citations · Full text

, , +17

1–5 of 32

Authors

180

  1. AW
    Arieh Warshel

    University of Southern California, United States

    2 publications · 76 citations

    2

    h-index

  2. WJ
    Wen Jun Xie

    Peking University, China

    2 publications · 76 citations

    2

    h-index

  3. JM
    Jong Min Kim

    Korea Advanced Institute of Science and Technology, South Korea

    1 publications · 48 citations

    1

    h-index

  4. CH
    Chang Hyuck Choi

    Korea Advanced Institute of Science and Technology, South Korea

    1 publications · 34 citations

    1

    h-index

  5. JP
    Jitendra Pal Singh

    Korea Institute of Science and Technology, South Korea

    1 publications · 48 citations

    1

    h-index

1–5 of 180

Institutions

87

  1. Chinese Academy of Sciences

    Beijing, China

    2 h-index

    13 publications

    214 citations

  2. University of Science and Technology of China

    Hefei, China

    2 h-index

    3 publications

    268 citations

  3. Pohang University of Science and Technology

    Pohang, South Korea

    2 h-index

    3 publications

    128 citations

  4. University College London

    London, United Kingdom

    2 h-index

    4 publications

    638 citations

  5. University of Southern California

    Los Angeles, United States

    2 h-index

    5 publications

    199 citations

  6. City University of Hong Kong

    Hong Kong, Hong Kong

    2 h-index

    9 publications

    358 citations

  7. Alborz University of Medical Sciences

    Karaj, Iran

    1 h-index

    1 publications

    49 citations

  8. Korea Institute of Industrial Technology

    Cheonan, South Korea

    1 h-index

    1 publications

    48 citations

1–8 of 87

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 7 publications · 497 citations

    7

    h-index

  2. Biochemistry

    3 publications · 328 citations

    3

    h-index

  3. ACS Catalysis

    2 publications · 141 citations

    2

    h-index

  4. Nature Communications

    2 publications · 237 citations

    2

    h-index

  5. Environmental Science & Technology

    1 publications · 49 citations

    1

    h-index

1–5