Concepedia

Spread Of Silencing

Spread of Silencing is a biological mechanism in the context of X-chromosome inactivation whereby the inactivated state of one X chromosome propagates linearly along the chromosomal axis, leading to the stable and heritable transcriptional repression of adjacent genes.

28

Publications

2.2K

Citations

138

Authors

58

Institutions

Publications per year

2017–2026

4

Parents

Publications

28

High-resolution Xist binding maps reveal two-step spreading during X-chromosome inactivation

Matthew D. Simon, Stefan F. Pinter, Rui Fang et al. · Nature · 2013 · 401 citations · Full text

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Xist recruits the X chromosome to the nuclear lamina to enable chromosome-wide silencing

Chun‐Kan Chen, Mario R. Blanco, Constanza Jackson et al. · Science · 2016 · 278 citations

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Xist Deletional Analysis Reveals an Interdependency between Xist RNA and Polycomb Complexes for Spreading along the Inactive X

David Colognori, Hongjae Sunwoo, Andrea J. Kriz et al. · Molecular Cell · 2019 · 182 citations · Full text

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Xist nucleates local protein gradients to propagate silencing across the X chromosome

Yolanda Markaki, Johnny Gan Chong, Yuying Wang et al. · Cell · 2021 · 140 citations · Full text

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The Spreading of X Inactivation into Autosomal Material of an X;autosome Translocation: Evidence for a Difference between Autosomal and X-Chromosomal DNA

Wendy White, H.F. Willard, D L Van Dyke et al. · The American Journal of Human Genetics · 1998 · 131 citations · Full text

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1–5 of 28

Authors

138

  1. TB
    Tatyana B. Nesterova

    University of Oxford, United Kingdom

    4 publications · 234 citations

    4

    h-index

  2. NB
    Neil Brockdorff

    University of Oxford, United Kingdom

    4 publications · 234 citations

    4

    h-index

  3. CJ
    Carolyn J. Brown

    University of British Columbia, Canada

    3 publications · 174 citations

    3

    h-index

  4. HC
    Heather Coker

    University of Oxford, United Kingdom

    2 publications · 98 citations

    2

    h-index

  5. JS
    Joseph S. Bowness

    University of Oxford, United Kingdom

    2 publications · 98 citations

    2

    h-index

1–5 of 138

Institutions

58

  1. University of Oxford

    Oxford, United Kingdom

    3 h-index

    23 publications

    1.2K citations

  2. University of British Columbia

    Vancouver, Canada

    3 h-index

    17 publications

    643 citations

  3. Child and Family Research Institute

    Vancouver, Canada

    2 h-index

    9 publications

    523 citations

  4. Massachusetts General Hospital

    Boston, United States

    2 h-index

    13 publications

    4.1K citations

  5. California Institute of Technology

    Pasadena, United States

    2 h-index

    12 publications

    2.8K citations

  6. Harvard University

    Cambridge, United States

    2 h-index

    13 publications

    4.1K citations

  7. Hammersmith Hospital

    London, United Kingdom

    2 h-index

    7 publications

    468 citations

  8. University of California San Diego

    San Diego, United States

    2 h-index

    2 publications

    188 citations

1–8 of 58

Venues

  1. Human Genetics

    3 publications · 124 citations

    3

    h-index

  2. Genetics

    3 publications · 87 citations

    3

    h-index

  3. Genome biology

    2 publications · 62 citations

    2

    h-index

  4. Human Molecular Genetics

    2 publications · 205 citations

    2

    h-index

  5. Science

    2 publications · 366 citations

    2

    h-index

1–5