Concepedia

Split-pool Synthesis

Split-Pool Synthesis is a combinatorial chemical synthesis method that involves the iterative division of a solid support into separate groups for individual reaction with different building blocks, followed by pooling and mixing to generate diverse compound libraries in a highly efficient manner.

60

Publications

3.9K

Citations

273

Authors

52

Institutions

Publications per year

2017–2026

9

Variants

Split-and-mix SynthesisSplit-and-pool Synthesis

Parents

Publications

60

Generating Diverse Skeletons of Small Molecules Combinatorially

Martin D. Burke, Eric M. Berger, Stuart L. Schreiber · Science · 2003 · 376 citations

, , +17

A Library of Spirooxindoles Based on a Stereoselective Three-Component Coupling Reaction

Michael M.‐C. Lo, Christopher S. Neumann, Satoshi Nagayama et al. · Journal of the American Chemical Society · 2004 · 273 citations

, , +15

Natural Product-like Combinatorial Libraries Based on Privileged Structures. 2. Construction of a 10 000-Membered Benzopyran Library by Directed Split-and-Pool Chemistry Using NanoKans and Optical Encoding

K. C. Nicolaou, Jeffrey A. Pfefferkorn, Helen J. Mitchell et al. · Journal of the American Chemical Society · 2000 · 270 citations

, , +17

Small-Molecule Inhibitors of Protein Geranylgeranyltransferase Type I

Sabrina Castellano, Hannah D.G. Fiji, Sape S. Kinderman et al. · Journal of the American Chemical Society · 2007 · 200 citations · Full text

, , +16

A Synthesis Strategy Yielding Skeletally Diverse Small Molecules Combinatorially

Martin D. Burke, Eric M. Berger, Stuart L. Schreiber · Journal of the American Chemical Society · 2004 · 187 citations

, , +16

1–5 of 60

Authors

273

  1. SL
    Stuart L. Schreiber

    Harvard University, United States

    11 publications · 1.5K citations

    11

    h-index

  2. TK
    Thomas Kodadek

    The University of Texas Southwestern Medical Center, United States

    5 publications · 165 citations

    5

    h-index

  3. MM
    Morten Meldal

    Carlsberg Laboratory, Denmark

    3 publications · 83 citations

    3

    h-index

  4. RA
    Robert A. Stavenger

    University of Illinois Urbana-Champaign, United States

    2 publications · 94 citations

    2

    h-index

  5. RH
    Ralph Holl

    University of Münster, Germany

    2 publications · 37 citations

    2

    h-index

1–5 of 273

Institutions

52

  1. Scripps Research Institute

    San Diego, United States

    12 h-index

    12 publications

    868 citations

  2. Harvard University

    Cambridge, United States

    12 h-index

    12 publications

    1.2K citations

  3. Howard Hughes Medical Institute

    Chevy Chase, United States

    11 h-index

    11 publications

    1.5K citations

  4. University of California San Diego

    San Diego, United States

    3 h-index

    3 publications

    364 citations

  5. Carlsberg Laboratory

    Copenhagen, Denmark

    3 h-index

    3 publications

    83 citations

  6. Broad Institute

    Cambridge, United States

    2 h-index

    2 publications

    460 citations

  7. Ludwig-Maximilians-Universität München

    Munich, Germany

    2 h-index

    2 publications

    78 citations

  8. Harvard Stem Cell Institute

    Cambridge, United States

    2 h-index

    2 publications

    68 citations

1–8 of 52

Venues

  1. Journal of the American Chemical Society

    JACS · 9 publications · 1.3K citations

    9

    h-index

  2. Journal of Combinatorial Chemistry

    6 publications · 297 citations

    6

    h-index

  3. Angewandte Chemie International Edition

    4 publications · 259 citations

    4

    h-index

  4. ACS Combinatorial Science

    3 publications · 99 citations

    3

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 3 publications · 304 citations

    3

    h-index

1–5