Concepedia

Spliceosome Catalysis

Spliceosome Catalysis is a biochemical process in which the spliceosome, a dynamic ribonucleoprotein complex composed of small nuclear RNAs and associated proteins, catalyzes the sequence-specific cleavage and ligation of precursor mRNA to excise introns and join exons during nuclear pre-mRNA splicing.

215

Publications

20.7K

Citations

675

Authors

239

Institutions

Publications per year

2017–2026

34

Parents

Publications

215

Crystal Structure of a Group I Ribozyme Domain: Principles of RNA Packing

J.H.D. Cate, Anne R. Gooding, Elaine R. Podell et al. · Science · 1996 · 1.2K citations

, , +17

A general two-metal-ion mechanism for catalytic RNA.

Thomas A. Steitz, J A Steitz · Proceedings of the National Academy of Sciences · 1993 · 1.2K citations

, , +17

A novel base-pairing interaction between U2 and U6 snRNAs suggests a mechanism for the catalytic activation of the spliceosome

Hiten D. Madhani, Christine Guthrie · Cell · 1992 · 437 citations

, , +13

Structure of the Dual Enzyme Ire1 Reveals the Basis for Catalysis and Regulation in Nonconventional RNA Splicing

Kenneth P.K. Lee, Madhusudan Dey, Dante Neculai et al. · Cell · 2008 · 385 citations · Full text

, , +12

Small Nuclear Ribonucleoprotein Remodeling During Catalytic Activation of the Spliceosome

Evgeny M. Makarov, Olga V. Makarova, Henning Urlaub et al. · Science · 2002 · 370 citations · Full text

, , +16

1–5 of 215

Authors

675

  1. RL
    Reinhard Lührmann

    Max Planck Institute for Biophysical Chemistry, Germany

    24 publications · 3.2K citations

    23

    h-index

  2. CL
    Cindy L. Will

    Max Planck Institute for Biophysical Chemistry, Germany

    14 publications · 2K citations

    14

    h-index

  3. HU
    Henning Urlaub

    Max Planck Institute for Biophysical Chemistry, Germany

    13 publications · 2.1K citations

    13

    h-index

  4. SC
    Soo-Chen Cheng

    Institute of Molecular Biology, Academia Sinica, Taiwan

    12 publications · 676 citations

    12

    h-index

  5. BK
    Berthold Kastner

    Max Planck Institute for Biophysical Chemistry, Germany

    9 publications · 1.4K citations

    9

    h-index

1–5 of 675

Institutions

239

  1. Max Planck Institute for Biophysical Chemistry

    Göttingen, Germany

    29 h-index

    169 publications

    20.2K citations

  2. Institute of Molecular Biology, Academia Sinica

    Taipei, Taiwan

    13 h-index

    49 publications

    2.9K citations

  3. Howard Hughes Medical Institute

    Chevy Chase, United States

    12 h-index

    23 publications

    6.8K citations

  4. University of Göttingen

    Göttingen, Germany

    12 h-index

    24 publications

    2.1K citations

  5. Tsinghua University

    Beijing, China

    11 h-index

    43 publications

    5.7K citations

  6. Center for Life Sciences

    Beijing, China

    10 h-index

    40 publications

    5.3K citations

  7. University of California, San Francisco

    San Francisco, United States

    10 h-index

    27 publications

    1.6K citations

  8. National Yang Ming Chiao Tung University

    Hsinchu, Taiwan

    9 h-index

    23 publications

    1.4K citations

1–8 of 239

Venues

  1. RNA

    35 publications · 1.9K citations

    25

    h-index

  2. Molecular and Cellular Biology

    MCB · 15 publications · 1.1K citations

    15

    h-index

  3. Science

    14 publications · 3.6K citations

    14

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 15 publications · 2.1K citations

    14

    h-index

  5. Genes & Development

    13 publications · 1.4K citations

    13

    h-index

1–5