Structure of the Dual Enzyme Ire1 Reveals the Basis for Catalysis and Regulation in Nonconventional RNA Splicing

Kenneth P.K. Lee, Madhusudan Dey, Dante Neculai, +3

Cell

Transcriptional RegulationNonconventional RnaNatural SciencesGeneticsRna Splicing +7

A Strategy for Modulation of Enzymes in the Ubiquitin System

Andreas Ernst, G.V. Avvakumov, Jiefei Tong, +28

Science

Ubiquitin VariantsProtein ChemistryProtein FunctionAldo-keto ReductaseCellular Enzymology +12

Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36

Dante Neculai, Michael Schwake, Mani Ravichandran, +12

Nature

Crystal StructureTheoretical Inorganic ChemistryMolecular BiologyStructural BiologyMedicine +3

Palmitoylation of NOD1 and NOD2 is required for bacterial sensing

Yan Lu, Yuping Zheng, Étienne Coyaud, +22

Science

InflammationMolecular ImmunologyAutoimmune DiseaseMembrane LocalizationMicrobial Proteomics +13

An Allosteric Inhibitor of the Human Cdc34 Ubiquitin-Conjugating Enzyme

Derek F. Ceccarelli, Xiaojing Tang, Benoit Pelletier, +22

Cell

MedicineAllosteric InhibitorDrug DevelopmentPharmacologyInhibitory Activity

Suprafacial Orientation of the SCFCdc4 Dimer Accommodates Multiple Geometries for Substrate Ubiquitination

Xiaojing Tang, Stephen Orlicky, Zhen‐Yuan Lin, +7

Cell

Materials ScienceEngineeringSuprafacial OrientationSurface ScienceSubstrate Ubiquitination +2

Human Cartilage-Derived Progenitor Cells From Committed Chondrocytes for Efficient Cartilage Repair and Regeneration

Yangzi Jiang, Youzhi Cai, Wei Zhang, +8

Stem Cells Translational Medicine

Tissue EngineeringEngineeringAdult Stem CellBone RepairStem Cell Biology +19

Elevated Coding Mutation Rate During the Reprogramming of Human Somatic Cells into Induced Pluripotent Stem Cells

Junfeng Ji, Siemon H. S. Ng, Vivek Sharma, +8

Stem Cells

Cell LineageInduced Pluripotent Stem CellSomatic VariantPoint Mutation LoadSomatic Cell Genetics +12

A novel assay uncovers an unexpected role for SR-BI in LDL transcytosis

Susan Armstrong, Michael G. Sugiyama, Karen Fung, +13

Cardiovascular Research

Lysosomal integral membrane protein-2 (LIMP-2/SCARB2) is involved in lysosomal cholesterol export

Saskia Heybrock, Kristiina Kanerva, Ying Meng, +17

Nature Communications