Concepedia

Splenic Aging Changes

Splenic Aging Changes is a biological phenomenon denoting the progressive structural and functional alterations in the spleen associated with advancing age, characterized by reduced lymphoid tissue, decreased immune responsiveness, and vascular modifications distinct from pathological conditions.

188

Publications

7.5K

Citations

690

Authors

220

Institutions

Publications per year

2017–2026

13

Parents

Publications

188

Lymphokines and aging: interleukin-2 production and activity in aged animals.

Marilyn L. Thoman, William O. Weigle · The Journal of Immunology · 1981 · 234 citations · Full text

, , +17

The splenic suppressor cell. I. Activity of thymus-dependent adherent cells: changes with age and stress.

Hugo Folch, Byron H. Waksman · PubMed · 1974 · 187 citations

, , +15

B Cell Maintenance in Aged Mice Reflects Both Increased B Cell Longevity and Decreased B Cell Generation

Gregory H. Kline, Tracy A. Hayden, Norman R. Klinman · The Journal of Immunology · 1999 · 172 citations · Full text

, , +17

The age-associated increase in IFN-gamma synthesis by mouse CD8+ T cells correlates with shifts in the frequencies of cell subsets defined by membrane CD44, CD45RB, 3G11, and MEL-14 expression.

David Ernst, W O Weigle, Daniel J. Noonan et al. · The Journal of Immunology · 1993 · 165 citations

, , +17

Splenic immunoglobulin-secreting cells and their regulation in autoimmune mice.

Argyrios N. Theofilopoulos, Daniel L. Shawler, Robert A. Eisenberg et al. · The Journal of Experimental Medicine · 1980 · 164 citations · Full text

, , +16

1–5 of 188

Authors

690

  1. TM
    Takashi Makinodan

    Oak Ridge National Laboratory, United States

    11 publications · 574 citations

    11

    h-index

  2. DF
    Daniela Frasca

    University of Miami, United States

    5 publications · 151 citations

    5

    h-index

  3. DL
    Denise L. Bellinger

    Loma Linda University, United States

    4 publications · 120 citations

    4

    h-index

  4. RL
    Richard L. Riley

    University of Miami, United States

    4 publications · 110 citations

    4

    h-index

  5. RL
    R. L. Walford

    University of California, Los Angeles, United States

    4 publications · 218 citations

    4

    h-index

1–5 of 690

Institutions

220

  1. University of California, Los Angeles

    Los Angeles, United States

    7 h-index

    21 publications

    1.1K citations

  2. Oak Ridge National Laboratory

    Oak Ridge, United States

    7 h-index

    24 publications

    899 citations

  3. Geriatric Research Education and Clinical Center

    Pittsburgh, United States

    6 h-index

    19 publications

    438 citations

  4. Scripps Research Institute

    San Diego, United States

    5 h-index

    18 publications

    1.8K citations

  5. National Institute on Aging

    Baltimore, United States

    5 h-index

    8 publications

    262 citations

  6. Scripps Health

    San Diego, United States

    5 h-index

    15 publications

    1.6K citations

  7. University of Belgrade

    Belgrade, Serbia

    5 h-index

    24 publications

    434 citations

  8. Cornell University

    Ithaca, United States

    4 h-index

    15 publications

    444 citations

1–8 of 220

Venues

  1. PubMed

    Repository · 21 publications · 1.1K citations

    19

    h-index

  2. The Journal of Immunology

    JI · 20 publications · 1.5K citations

    17

    h-index

  3. Mechanisms of Ageing and Development

    17 publications · 621 citations

    15

    h-index

  4. Experimental Gerontology

    8 publications · 186 citations

    8

    h-index

  5. Cellular Immunology

    7 publications · 256 citations

    7

    h-index

1–5