Concepedia

Specificity Engineering

Specificity Engineering is a methodological approach in synthetic biology that involves the rational design and optimization of molecular interactions in whole-cell biosensors or yeast surface display systems to enhance selective recognition of target ligands while minimizing cross-reactivity with non-target molecules.

39

Publications

2.1K

Citations

223

Authors

91

Institutions

Publications per year

2017–2026

23

Parents

Publications

39

Automated design of specificity in molecular recognition

James J. Havranek, Pehr B. Harbury · Nature Structural Biology · 2002 · 313 citations

, , +14

Genetic Screens and Selections for Small Molecules Based on a Synthetic Riboswitch That Activates Protein Translation

Shawn K. Desai, Justin P. Gallivan · Journal of the American Chemical Society · 2004 · 211 citations

, , +15

Alteration of the Substrate Specificity of a Modular Polyketide Synthase Acyltransferase Domain through Site-Specific Mutations

Christopher D. Reeves, Sumati Murli, Gary W. Ashley et al. · Biochemistry · 2001 · 192 citations

, , +17

Evolution-guided engineering of small-molecule biosensors

Tim Snoek, Evan Kirk Chaberski, Francesca Ambri et al. · Nucleic Acids Research · 2019 · 139 citations · Full text

, , +15

Engineering and application of a biosensor with focused ligand specificity

Dennis Della Corte, Hugo L. van Beek, Falk Syberg et al. · Nature Communications · 2020 · 107 citations · Full text

, , +17

1–5 of 39

Authors

223

  1. JD
    Jay D. Keasling

    University of California, Berkeley, United States

    4 publications · 256 citations

    4

    h-index

  2. MK
    Michael K. Jensen

    Rensselaer Polytechnic Institute, United States

    4 publications · 256 citations

    4

    h-index

  3. TS
    Tim Snoek

    Novo Nordisk Foundation, Denmark

    3 publications · 229 citations

    3

    h-index

  4. FA
    Francesca Ambri

    Novo Nordisk Foundation, Denmark

    3 publications · 229 citations

    3

    h-index

  5. SP
    Sara Petersen Bjørn

    Technical University of Denmark, Denmark

    2 publications · 151 citations

    2

    h-index

1–5 of 223

Institutions

91

  1. Technical University of Denmark

    Kongens Lyngby, Denmark

    5 h-index

    32 publications

    2K citations

  2. University of California, Berkeley

    Berkeley, United States

    4 h-index

    4 publications

    256 citations

  3. Joint BioEnergy Institute

    Emeryville, United States

    4 h-index

    8 publications

    558 citations

  4. Lawrence Berkeley National Laboratory

    Berkeley, United States

    4 h-index

    4 publications

    256 citations

  5. Novo Nordisk Foundation

    Copenhagen, Denmark

    4 h-index

    28 publications

    1.9K citations

  6. RWTH Aachen University

    Aachen, Germany

    3 h-index

    5 publications

    211 citations

  7. Massachusetts Institute of Technology

    Cambridge, United States

    2 h-index

    4 publications

    67 citations

  8. Heinrich Heine University Düsseldorf

    Düsseldorf, Germany

    2 h-index

    3 publications

    153 citations

1–8 of 91

Venues

  1. ACS Synthetic Biology

    5 publications · 282 citations

    5

    h-index

  2. Protein Engineering Design and Selection

    PEDS · 2 publications · 39 citations

    2

    h-index

  3. Biochemistry

    2 publications · 264 citations

    2

    h-index

  4. bioRxiv (Cold Spring Harbor Laboratory)

    Repository · 2 publications · 25 citations

    2

    h-index

  5. ACS Chemical Biology

    2 publications · 79 citations

    2

    h-index

1–5