Gary W. Ashley

Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel “unnatural” natural products

Robert McDaniel, Arinthip Thamchaipenet, Claes Gustafsson et al. · Proceedings of the National Academy of Sciences · 1999 · 457 citations · Full text

Hydrogel drug delivery system with predictable and tunable drug release and degradation rates

Gary W. Ashley, Jeff Henise, Ralph R. Reid et al. · Proceedings of the National Academy of Sciences · 2013 · 365 citations · Full text

A Model of Structure and Catalysis for Ketoreductase Domains in Modular Polyketide Synthases

Ralph Reid, Misty Piagentini, Eduardo Rodrı́guez et al. · Biochemistry · 2002 · 308 citations

Biosynthesis, Biotin Recognition Sequence, Engineering +15

<i>Escherichia coli</i> LipA Is a Lipoyl Synthase:  In Vitro Biosynthesis of Lipoylated Pyruvate Dehydrogenase Complex from Octanoyl-Acyl Carrier Protein

J. Richard Miller, Robert Busby, Sean W. Jordan et al. · Biochemistry · 2000 · 204 citations

Lipa Catalysis, Bacteriology, Microbial Physiology +18

Alteration of the Substrate Specificity of a Modular Polyketide Synthase Acyltransferase Domain through Site-Specific Mutations

Christopher D. Reeves, Sumati Murli, Gary W. Ashley et al. · Biochemistry · 2001 · 189 citations

Substrate Selectivity, Engineering, Molecular Biology +17