Concepedia

Specificity Constant

The Specificity Constant is a kinetic parameter that belongs to the class of enzyme efficiency metrics, specifically defined as the ratio of the catalytic rate constant to the Michaelis constant (kcat/Km), distinguishing it by quantifying an enzyme's preference for a particular substrate among alternatives under physiological conditions.

155

Publications

8.1K

Citations

627

Authors

231

Institutions

Publications per year

2017–2026

8

Variants

Kcat/km

Parents

Publications

155

Fhit, a Putative Tumor Suppressor in Humans, Is a Dinucleoside 5‘,5‘ ‘‘-P<sup>1</sup>,P<sup>3</sup>-Triphosphate Hydrolase

Larry D. Barnes, Preston N. Garrison, Zurab Siprashvili et al. · Biochemistry · 1996 · 352 citations

, , +7

Catalytic efficiency and kcat/KM: a useful comparator?

Robert Eisenthal, Michael J. Danson, David W. Hough · Trends in biotechnology · 2007 · 316 citations

, , +10

Kinetics of Carboxypeptidase Action. I. Effect of Various Extrinsic Factors on Kinetic Parameters<sup>1</sup>

Rufus Lumry, Emil L. Smith, Ruby R. Glantz · Journal of the American Chemical Society · 1951 · 213 citations

, , +14

The Τumor Necrosis Factor-α Converting Enzyme (TACE):  A Unique Metalloproteinase with Highly Defined Substrate Selectivity

Mohita J. Mohan, Theresa Seaton, Justin Mitchell et al. · Biochemistry · 2002 · 199 citations

, , +13

Dipeptidyl-Peptidase IV Converts Intact B-Type Natriuretic Peptide into Its des-SerPro Form

Inger Brandt, Anne‐Marie Lambeir, Jean‐Marie Ketelslegers et al. · Clinical Chemistry · 2005 · 189 citations

, , +16

1–5 of 155

Authors

627

  1. KA
    Kenneth A. Johnson

    The University of Texas at Austin, United States

    6 publications · 350 citations

    6

    h-index

  2. CE
    Christian EIS

    BOKU University, Austria

    3 publications · 89 citations

    3

    h-index

  3. BN
    Bernd Nidetzky

    Graz University of Technology, Austria

    3 publications · 89 citations

    3

    h-index

  4. MT
    Mohamad Takwa

    KTH Royal Institute of Technology, Sweden

    2 publications · 167 citations

    2

    h-index

  5. AO
    Anders O. Magnusson

    KTH Royal Institute of Technology, Sweden

    2 publications · 167 citations

    2

    h-index

1–5 of 627

Institutions

231

  1. Centre National de la Recherche Scientifique

    Paris, France

    8 h-index

    21 publications

    1.6K citations

  2. The University of Texas at Austin

    Austin, United States

    7 h-index

    14 publications

    838 citations

  3. Inserm

    Paris, France

    4 h-index

    14 publications

    592 citations

  4. Commissariat à l'Énergie Atomique et aux Énergies Alternatives

    Paris, France

    3 h-index

    7 publications

    458 citations

  5. Queen's University Belfast

    Belfast, United Kingdom

    3 h-index

    15 publications

    646 citations

  6. University of Michigan

    Ann Arbor, United States

    3 h-index

    10 publications

    610 citations

  7. BOKU University

    Vienna, Austria

    3 h-index

    6 publications

    178 citations

  8. University of California, Berkeley

    Berkeley, United States

    2 h-index

    3 publications

    209 citations

1–8 of 231

Venues

  1. Biochemistry

    31 publications · 2K citations

    26

    h-index

  2. Journal of Biological Chemistry

    JBC · 21 publications · 1.4K citations

    19

    h-index

  3. Biochemical Journal

    BJ · 14 publications · 392 citations

    11

    h-index

  4. Journal of the American Chemical Society

    JACS · 9 publications · 623 citations

    9

    h-index

  5. European Journal of Biochemistry

    EJB · 5 publications · 132 citations

    5

    h-index

1–5