Concepedia

Spatial Signaling Dynamics

Spatial Signaling Dynamics is a theoretical framework that characterizes the spatiotemporal organization and propagation of molecular signals within cellular environments, distinguishing itself by explicitly integrating spatial heterogeneity and dynamic signaling processes to elucidate context-dependent regulatory mechanisms in engineered biological systems.

64

Publications

4.5K

Citations

260

Authors

111

Institutions

Publications per year

2017–2026

17

Parents

Publications

64

Spatial Organization of Hippo Signaling at the Plasma Membrane Mediated by the Tumor Suppressor Merlin/NF2

Jianzhong Yu, Yonggang Zheng, Qian Chen et al. · Cell · 2013 · 515 citations · Full text

, , +16

Cell Shape and Negative Links in Regulatory Motifs Together Control Spatial Information Flow in Signaling Networks

Susana R. Neves, Panayiotis Tsokas, A. Sarkar et al. · Cell · 2008 · 288 citations · Full text

, , +16

Multidimensional Tracking of GPCR Signaling via Peroxidase-Catalyzed Proximity Labeling

Jaeho Paek, Marian Kalocsay, Dean P. Staus et al. · Cell · 2017 · 287 citations · Full text

, , +10

Competing Patterns of Signaling Activity in<i>Dictyostelium Discoideum</i>

Kyoung J. Lee, Edward C. Cox, Raymond E. Goldstein · Physical Review Letters · 1996 · 205 citations · Full text

, , +15

Systems analysis of EGF receptor signaling dynamics with microwestern arrays

Mark F. Ciaccio, Joel P. Wagner, Chih‐Pin Chuu et al. · Nature Methods · 2010 · 192 citations · Full text

, , +16

1–5 of 64

Authors

260

  1. SY
    Stanislav Y. Shvartsman

    Princeton University, United States

    3 publications · 265 citations

    3

    h-index

  2. RN
    Ronald N. Germain

    National Institute of Allergy and Infectious Diseases, United States

    3 publications · 186 citations

    3

    h-index

  3. DA
    Douglas A. Lauffenburger

    Massachusetts Institute of Technology, United States

    3 publications · 434 citations

    3

    h-index

  4. II
    Ion I. Moraru

    UConn Health, United States

    2 publications · 446 citations

    2

    h-index

  5. BΝ
    Boris Ν. Kholodenko

    University College Dublin, Ireland

    2 publications · 78 citations

    2

    h-index

1–5 of 260

Institutions

111

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    5 h-index

    16 publications

    3.9K citations

  2. Princeton University

    Princeton, United States

    4 h-index

    9 publications

    1K citations

  3. National Institute of Allergy and Infectious Diseases

    Bethesda, United States

    3 h-index

    11 publications

    852 citations

  4. Massachusetts Institute of Technology

    Cambridge, United States

    3 h-index

    6 publications

    884 citations

  5. University of California, San Francisco

    San Francisco, United States

    3 h-index

    15 publications

    1.6K citations

  6. University of California San Diego

    San Diego, United States

    3 h-index

    10 publications

    540 citations

  7. National Institutes of Health

    Bethesda, United States

    2 h-index

    9 publications

    698 citations

  8. Center for Systems Biology

    Boston, United States

    2 h-index

    2 publications

    92 citations

1–8 of 111

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 5 publications · 320 citations

    5

    h-index

  2. Biophysical Journal

    5 publications · 290 citations

    5

    h-index

  3. Cell

    5 publications · 1.3K citations

    5

    h-index

  4. PLoS Computational Biology

    4 publications · 144 citations

    4

    h-index

  5. Journal of Mathematical Biology

    3 publications · 74 citations

    3

    h-index

1–5