Somatic Mutation Accumulation is a biological phenomenon characterized by the progressive increase in DNA sequence alterations occurring in non-germline cells over an organism's lifespan, driven by replication errors, environmental insults, and compromised DNA repair mechanisms.
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224
Clock-like mutational processes in human somatic cells
Ludmil B. Alexandrov, Philip H. Jones, David C. Wedge et al. · Nature Genetics · 2015 · 1.2K citations · Full text
Tissue-specific mutation accumulation in human adult stem cells during life
Francis Blokzijl, Joep de Ligt, Myrthe Jager et al. · Nature · 2016 · 984 citations · Full text
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Wellcome Sanger Institute
Cambridge, United Kingdom
10 h-index
103 publications
28K citations
University of Cambridge
Cambridge, United Kingdom
10 h-index
25 publications
8.8K citations
Harvard University
Cambridge, United States
9 h-index
38 publications
3.3K citations
Kyoto University
Kyoto, Japan
7 h-index
47 publications
4.6K citations
National Institutes of Health
Bethesda, United States
7 h-index
44 publications
2.3K citations
Howard Hughes Medical Institute
Chevy Chase, United States
6 h-index
21 publications
2.9K citations
Albert Einstein College of Medicine
Bronx, United States
6 h-index
36 publications
2K citations
École Polytechnique Fédérale de Lausanne
Lausanne, Switzerland
6 h-index
8 publications
403 citations
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- Nature
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- Mutation research. Fundamental and molecular mechanisms of mutagenesis
10 publications · 469 citations
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PNAS · 9 publications · 1.1K citations
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7 publications · 540 citations
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6 publications · 1.9K citations
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