Concepedia

Site-specific Protein Modification

Site-Specific Protein Modification is a chemical or enzymatic method that enables the selective alteration of a defined site within a protein sequence, distinguished from nonspecific modification techniques by its precise spatial control over conjugation or labeling.

242

Publications

17.7K

Citations

1.2K

Authors

344

Institutions

Publications per year

2017–2026

76

Parents

Publications

242

Site-selective protein-modification chemistry for basic biology and drug development

Nikolaus Krall, Filipa P. da Cruz, Omar Boutureira et al. · Nature Chemistry · 2015 · 582 citations

, , +16

Genetic Encoding of Bicyclononynes and <i>trans</i>-Cyclooctenes for Site-Specific Protein Labeling in Vitro and in Live Mammalian Cells via Rapid Fluorogenic Diels–Alder Reactions

Kathrin Lang, Lloyd Davis, Stephen Wallace et al. · Journal of the American Chemical Society · 2012 · 524 citations · Full text

, , +13

Genetically encoded short peptide tag for versatile protein labeling by Sfp phosphopantetheinyl transferase

Jun Yin, Paul D. Straight, Shaun M. McLoughlin et al. · Proceedings of the National Academy of Sciences · 2005 · 428 citations · Full text

, , +17

Decarboxylative alkylation for site-selective bioconjugation of native proteins via oxidation potentials

Steven Bloom, Chun Liu, Dominik K. Kölmel et al. · Nature Chemistry · 2017 · 380 citations · Full text

, , +16

A “Tag-and-Modify” Approach to Site-Selective Protein Modification

Justin M. Chalker, Gonçalo J. L. Bernardes, Benjamin G. Davis · Accounts of Chemical Research · 2011 · 354 citations

, , +12

1–5 of 242

Authors

1.2K

  1. JY
    Jun Yin

    Georgia State University, United States

    7 publications · 1.3K citations

    7

    h-index

  2. AY
    Alice Y. Ting

    Massachusetts Institute of Technology, United States

    6 publications · 926 citations

    6

    h-index

  3. GJ
    Gonçalo J. L. Bernardes

    University of Cambridge, United Kingdom

    6 publications · 1.5K citations

    6

    h-index

  4. DR
    David Rabuka

    Howard Hughes Medical Institute, United States

    6 publications · 918 citations

    6

    h-index

  5. AD
    Alexander Deiters

    North Carolina State University, United States

    5 publications · 415 citations

    5

    h-index

1–5 of 1.2K

Institutions

344

  1. University of California, Berkeley

    Berkeley, United States

    14 h-index

    46 publications

    7.1K citations

  2. Peking University

    Beijing, China

    12 h-index

    64 publications

    5K citations

  3. Harvard University

    Cambridge, United States

    9 h-index

    50 publications

    11.3K citations

  4. Massachusetts Institute of Technology

    Cambridge, United States

    9 h-index

    34 publications

    4.7K citations

  5. Beijing National Laboratory for Molecular Sciences

    Beijing, China

    7 h-index

    37 publications

    3.5K citations

  6. Howard Hughes Medical Institute

    Chevy Chase, United States

    7 h-index

    26 publications

    2.8K citations

  7. Center for Life Sciences

    Beijing, China

    6 h-index

    14 publications

    1.3K citations

  8. ETH Zurich

    Zurich, Switzerland

    6 h-index

    21 publications

    2K citations

1–8 of 344

Venues

  1. Journal of the American Chemical Society

    JACS · 24 publications · 3K citations

    24

    h-index

  2. Bioconjugate Chemistry

    29 publications · 1.2K citations

    21

    h-index

  3. Journal of Biological Chemistry

    JBC · 17 publications · 966 citations

    16

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 11 publications · 2K citations

    11

    h-index

  5. Chemical Science

    9 publications · 564 citations

    9

    h-index

1–5