Concepedia

Staudinger Ligation

Staudinger Ligation is a bioorthogonal chemoselective ligation reaction in which an organic azide reacts with a phosphine reagent bearing an electrophilic trap to form, via an iminophosphorane intermediate, a stable amide bond under aqueous, metal-free conditions without cross-reacting with native biological functionalities.

277

Publications

25.5K

Citations

866

Authors

292

Institutions

Publications per year

2017–2026

42

Parents

Children

Publications

277

A Strain-Promoted [3 + 2] Azide−Alkyne Cycloaddition for Covalent Modification of Biomolecules in Living Systems

Nicholas J. Agard, Jennifer A. Prescher, Carolyn R. Bertozzi · Journal of the American Chemical Society · 2004 · 2.9K citations

, , +10

Cell Surface Engineering by a Modified Staudinger Reaction

Eliana Saxon, Carolyn R. Bertozzi · Science · 2000 · 2.4K citations

, , +17

Organic Azides: An Exploding Diversity of a Unique Class of Compounds

Stefan Bräse, Carmen Gil, Kerstin Knepper et al. · Angewandte Chemie International Edition · 2005 · 2.2K citations

, , +13

Incorporation of azides into recombinant proteins for chemoselective modification by the Staudinger ligation

Kristi L. Kiick, Eliana Saxon, David A. Tirrell et al. · Proceedings of the National Academy of Sciences · 2001 · 913 citations · Full text

, , +12

Recent advances in the staudinger reaction

Yuri G. Gololobov, L. F. Kasukhin · Tetrahedron · 1992 · 777 citations

, , +3

1–5 of 277

Authors

866

  1. RT
    Ronald T. Raines

    University of Wisconsin–Madison, United States

    13 publications · 1.8K citations

    13

    h-index

  2. CR
    Carolyn R. Bertozzi

    Howard Hughes Medical Institute, United States

    12 publications · 9.1K citations

    12

    h-index

  3. CP
    Christian P. R. Hackenberger

    Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Germany

    7 publications · 340 citations

    7

    h-index

  4. MB
    Matthew B. Soellner

    University of Michigan, United States

    7 publications · 830 citations

    7

    h-index

  5. AB
    Anna Bernardi

    University of Milan, Italy

    7 publications · 260 citations

    7

    h-index

1–5 of 866

Institutions

292

  1. University of Wisconsin–Madison

    Madison, United States

    18 h-index

    53 publications

    6.4K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    11 h-index

    33 publications

    15.7K citations

  3. Centre National de la Recherche Scientifique

    Paris, France

    11 h-index

    46 publications

    1.9K citations

  4. The University of Tokyo

    Tokyo, Japan

    8 h-index

    36 publications

    1.1K citations

  5. Lawrence Berkeley National Laboratory

    Berkeley, United States

    8 h-index

    23 publications

    14.1K citations

  6. University of Milan

    Milan, Italy

    7 h-index

    18 publications

    629 citations

  7. University of California, Berkeley

    Berkeley, United States

    7 h-index

    22 publications

    11.5K citations

  8. Helmholtz-Zentrum Dresden-Rossendorf

    Dresden, Germany

    5 h-index

    10 publications

    246 citations

1–8 of 292

Venues

  1. Journal of the American Chemical Society

    JACS · 19 publications · 5.4K citations

    19

    h-index

  2. Tetrahedron Letters

    27 publications · 820 citations

    17

    h-index

  3. Angewandte Chemie International Edition

    17 publications · 3.8K citations

    17

    h-index

  4. Tetrahedron

    16 publications · 1.2K citations

    15

    h-index

  5. The Journal of Organic Chemistry

    JOC · 16 publications · 954 citations

    15

    h-index

1–5