Concepedia

Site-directed Cleavage

Site-Directed Cleavage is a nucleic acid cleavage method that enables the precise targeting and cleavage of specific DNA or RNA sequences through the guided action of engineered nucleases or sequence-specific binding agents.

1.2K

Publications

84.9K

Citations

4.7K

Authors

1.1K

Institutions

Publications per year

2017–2026

84

Parents

Publications

1.2K

RNA interference is mediated by 21- and 22-nucleotide RNAs

Sayda M. Elbashir, Winfried Lendeckel, Thomas Tuschl · Genes & Development · 2001 · 3.3K citations · Full text

, , +15

A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells

Markus Hoffmann, Hannah Kleine‐Weber, Stefan Pöhlmann · Molecular Cell · 2020 · 2.1K citations · Full text

, , +17

The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade

Bruno Coutard, Coralie Valle, Xavier de Lamballerie et al. · Antiviral Research · 2020 · 1.8K citations

, , +17

Proteolytic Inactivation of MAP-Kinase-Kinase by Anthrax Lethal Factor

Nicholas S. Duesbery, Craig P. Webb, Stephen H. Leppla et al. · Science · 1998 · 1K citations

, , +13

Tobacco etch virus protease: mechanism of autolysis and rational design of stable mutants with wild-type catalytic proficiency

Rachel B. Kapust, József Tőzsér, Jeffrey D. Fox et al. · Protein Engineering Design and Selection · 2001 · 879 citations · Full text

, , +17

1–5 of 1.2K

Authors

4.7K

  1. LA
    Leif A. Kirsebom

    Uppsala University, Sweden

    11 publications · 359 citations

    10

    h-index

  2. SS
    Stewart Shuman

    Kettering University, United States

    9 publications · 466 citations

    9

    h-index

  3. MI
    Masayori Inouye

    Johnson University, United States

    8 publications · 675 citations

    8

    h-index

  4. WG
    Wolfgang Garten

    Philipps University of Marburg, Germany

    8 publications · 1.3K citations

    8

    h-index

  5. NG
    Nabil G. Seidah

    Montreal Clinical Research Institute, Canada

    7 publications · 2.5K citations

    7

    h-index

1–5 of 4.7K

Institutions

1.1K

  1. Centre National de la Recherche Scientifique

    Paris, France

    21 h-index

    87 publications

    10.2K citations

  2. National Institutes of Health

    Bethesda, United States

    18 h-index

    89 publications

    11.6K citations

  3. Howard Hughes Medical Institute

    Chevy Chase, United States

    18 h-index

    56 publications

    16.7K citations

  4. Harvard University

    Cambridge, United States

    17 h-index

    69 publications

    6.2K citations

  5. Yale University

    New Haven, United States

    15 h-index

    44 publications

    4.3K citations

  6. University of Washington

    Seattle, United States

    14 h-index

    52 publications

    4.8K citations

  7. The University of Tokyo

    Tokyo, Japan

    13 h-index

    63 publications

    2.8K citations

  8. Inserm

    Paris, France

    13 h-index

    59 publications

    6.5K citations

1–8 of 1.1K

Venues

  1. Journal of Biological Chemistry

    JBC · 152 publications · 11.9K citations

    61

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 90 publications · 8K citations

    59

    h-index

  3. Nucleic Acids Research

    117 publications · 6.1K citations

    41

    h-index

  4. Journal of Virology

    JVI · 70 publications · 4.9K citations

    41

    h-index

  5. Biochemistry

    48 publications · 2.5K citations

    29

    h-index

1–5