Concepedia

Sinusoidal Perfusion Model

Sinusoidal Perfusion Model is a mathematical framework used in hepatic pharmacokinetics that specifically characterizes the distribution and metabolism of drugs within the liver by modeling blood flow and substance exchange at the level of the hepatic sinusoids, distinguishing it from whole-organ or cellular-level perfusion models.

31

Publications

1.2K

Citations

102

Authors

40

Institutions

Publications per year

2017–2026

1

Parents

Publications

31

MODULATION OF KUPFFER CELL ACTIVITY BY GADOLINIUM CHLORIDE IN ENDOTOXEMIC RATS

Brigitte Vollmar, Dominik Rüttinger, Guido A. Wanner et al. · Shock · 1996 · 100 citations

, , +17

A biphasic model for sinusoidal liver perfusion remodeling after outflow obstruction

Tim Ricken, Uta Dahmen, Olaf Dirsch · Biomechanics and Modeling in Mechanobiology · 2010 · 96 citations

, , +15

Functional significance of endothelin B receptors in mediating sinusoidal and extrasinusoidal effects of endothelins in the intact rat liver

Michael Bauer, Inge Bauer, Natalie Sonin et al. · Hepatology · 2000 · 91 citations

, , +15

Effect of sinusoidal perfusion on galactose elimination kinetics in perfused rat liver.

Susanne Keiding, E Chiarantini · Journal of Pharmacology and Experimental Therapeutics · 1978 · 89 citations

, , +13

Discrimination between the venous equilibrium and sinusoidal models of hepatic drug elimination in the isolated perfused rat liver by perturbation of propranolol protein binding.

D B Jones, Denis J. Morgan, George W. Mihaly et al. · Journal of Pharmacology and Experimental Therapeutics · 1984 · 53 citations

, , +17

1–5 of 31

Authors

102

  1. SK
    Susanne Keiding

    Aarhus University Hospital, Denmark

    4 publications · 156 citations

    4

    h-index

  2. LB
    L. Bass

    The University of Queensland, Australia

    4 publications · 113 citations

    4

    h-index

  3. MD
    Michael D. Menger

    Saarland University, Germany

    3 publications · 163 citations

    3

    h-index

  4. KS
    K. Sandy Pang

    University of Toronto, Canada

    2 publications · 69 citations

    2

    h-index

  5. RA
    Richard A. Weisiger

    University of California, San Francisco, United States

    2 publications · 90 citations

    2

    h-index

1–5 of 102

Institutions

40

  1. Saarland University

    Saarbrücken, Germany

    4 h-index

    8 publications

    322 citations

  2. The University of Queensland

    Brisbane, Australia

    3 h-index

    5 publications

    122 citations

  3. University of California, San Francisco

    San Francisco, United States

    2 h-index

    6 publications

    270 citations

  4. University of Groningen

    Groningen, The Netherlands

    2 h-index

    8 publications

    122 citations

  5. University of Toronto

    Toronto, Canada

    2 h-index

    9 publications

    270 citations

  6. National Institute on Aging

    Baltimore, United States

    1 h-index

    2 publications

    28 citations

  7. University of Pennsylvania

    Philadelphia, United States

    1 h-index

    1 publications

    24 citations

  8. Berlin Heart (Germany)

    Berlin, Germany

    1 h-index

    1 publications

    96 citations

1–8 of 40

Venues

  1. 4

    h-index

  2. Hepatology

    3 publications · 170 citations

    3

    h-index

  3. 2

    h-index

  4. 2

    h-index

  5. Journal of Pharmaceutical Sciences

    1 publications · 48 citations

    1

    h-index

1–5