Concepedia

Single-particle Reconstruction

Single-Particle Reconstruction is a computational method in structural biology that belongs to the class of three-dimensional electron microscopy techniques, distinguished by its ability to determine high-resolution macromolecular structures from two-dimensional projection images of individual, randomly oriented virus particles frozen in vitreous ice.

380

Publications

37.5K

Citations

1.6K

Authors

500

Institutions

Publications per year

2017–2026

122

Variants

Single Particle Reconstruction

Parents

Publications

380

EMAN: Semiautomated Software for High-Resolution Single-Particle Reconstructions

Steven J. Ludtke, Philip R. Baldwin, Wah Chiu · Journal of Structural Biology · 1999 · 2.4K citations

, , +10

Non-uniform refinement: adaptive regularization improves single-particle cryo-EM reconstruction

Ali Punjani, Haowei Zhang, David J. Fleet · Nature Methods · 2020 · 1.9K citations

, , +10

3D variability analysis: Resolving continuous flexibility and discrete heterogeneity from single particle cryo-EM

Ali Punjani, David J. Fleet · Journal of Structural Biology · 2021 · 1.1K citations

, , +11

cisTEM, user-friendly software for single-particle image processing

Timothy Grant, Alexis Rohou, Nikolaus Grigorieff · eLife · 2018 · 994 citations · Full text

, , +17

The reconstruction of a three-dimensional structure from projections and its application to electron microscopy

R.A. Crowther, David J. DeRosier, Aaron Klug · Proceedings of the Royal Society of London A Mathematical and Physical Sciences · 1970 · 973 citations

, , +15

1–5 of 380

Authors

1.6K

  1. CÓ
    Carlos Óscar S. Sorzano

    Centro Nacional de Biotecnología, Spain

    18 publications · 952 citations

    14

    h-index

  2. JC
    J.M. Carazo

    Centro Nacional de Biotecnología, Spain

    17 publications · 1K citations

    14

    h-index

  3. WC
    Wah Chiu

    Baylor College of Medicine, United States

    12 publications · 3.1K citations

    11

    h-index

  4. JF
    Joachim Frank

    Wadsworth Center, United States

    11 publications · 1.4K citations

    11

    h-index

  5. RM
    R. Marabini

    Centro Nacional de Biotecnología, Spain

    11 publications · 800 citations

    11

    h-index

1–5 of 1.6K

Institutions

500

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    26 h-index

    67 publications

    11.2K citations

  2. Lawrence Berkeley National Laboratory

    Berkeley, United States

    22 h-index

    74 publications

    6.6K citations

  3. Centro Nacional de Biotecnología

    Madrid, Spain

    17 h-index

    111 publications

    6.2K citations

  4. Baylor College of Medicine

    Houston, United States

    17 h-index

    48 publications

    8.1K citations

  5. MRC Laboratory of Molecular Biology

    Cambridge, United Kingdom

    17 h-index

    49 publications

    12.3K citations

  6. Centre National de la Recherche Scientifique

    Paris, France

    14 h-index

    44 publications

    6K citations

  7. European Molecular Biology Laboratory

    Hamburg, Germany

    13 h-index

    35 publications

    5.3K citations

  8. Harvard University

    Cambridge, United States

    13 h-index

    37 publications

    3.3K citations

1–8 of 500

Venues

  1. Journal of Structural Biology

    78 publications · 9.4K citations

    37

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 23 publications · 3.1K citations

    22

    h-index

  3. Journal of Molecular Biology

    JMB · 16 publications · 1.2K citations

    15

    h-index

  4. Nature Communications

    11 publications · 1.2K citations

    11

    h-index

  5. bioRxiv (Cold Spring Harbor Laboratory)

    Repository · 10 publications · 398 citations

    10

    h-index

1–5