Silencer Elements

Silencer Elements is a type of cis-regulatory DNA sequence that functions to repress transcription of associated genes by providing binding sites for transcriptional repressor proteins, thereby distinguishing it from other regulatory elements such as enhancers or promoters that activate gene expression.

569

Publications

52.4K

Citations

2.4K

Authors

620

Institutions

Publications per year

2017–2026

Variants

Silencers

Parents

Gene StructureTranscriptional Regulation

Children

Cell Type-specific SilencingCis-regulatory Silencer ElementsComputational Prediction Of SilencersDisease-associated Silencer MutationsFunctional Validation Of SilencersGene-specific SilencingInsulator CrosstalkNoncoding Regulatory VariantsRepressive Chromatin MarksSilencer Binding Sites

Publications

569

Genome-Wide Mapping of in Vivo Protein-DNA Interactions

David S. Johnson, A Mortazavi, R Myers et al. · Science · 2007 · 3K citations

Life Sciences, Genetics, Molecular Biology +17

The Neuron-Restrictive Silencer Factor (NRSF): A Coordinate Repressor of Multiple Neuron-Specific Genes

Christopher J. Schoenherr, David J. Anderson · Science · 1995 · 1.1K citations

Medicine, Genetics, Molecular Biology +17

REST: A mammalian silencer protein that restricts sodium channel gene expression to neurons

Jayhong A. Chong, José Tapia-Ramı́rez, Sandra Kim et al. · Cell · 1995 · 1.1K citations · Full text

Life Sciences, Genetics, Neuroscience +17

Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases

Dirk Hockemeyer, Frank Soldner, Caroline Beard et al. · Nature Biotechnology · 2009 · 1.1K citations · Full text

Life Sciences, Genetics, Molecular Biology +14

Systematic Identification and Analysis of Exonic Splicing Silencers

Zefeng Wang, Michael E. Rolish, G Yeo et al. · Cell · 2004 · 691 citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +10

1–5 of 569

Authors

2.4K

JR
Jasper Rine
University of California, Berkeley, United States
19 publications · 2.6K citations
18
h-index
DS
David Shore
University of Geneva, Switzerland
10 publications · 1.6K citations
10
h-index
ZE
Zendra E. Zehner
Virginia Commonwealth University Medical Center, United States
9 publications · 318 citations
9
h-index
JR
James R. Broach
Princeton University, United States
9 publications · 662 citations
9
h-index
DS
Dinah S. Singer
National Cancer Institute, United States
7 publications · 219 citations
7
h-index

1–5 of 2.4K

Institutions

620

1–8 of 620

Venues

Molecular and Cellular Biology
MCB · 72 publications · 5.6K citations
41
h-index
Journal of Biological Chemistry
JBC · 48 publications · 2.4K citations
32
h-index
Proceedings of the National Academy of Sciences
PNAS · 27 publications · 3.7K citations
25
h-index
Nucleic Acids Research
24 publications · 1.5K citations
21
h-index
The EMBO Journal
16 publications · 3K citations
16
h-index

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