Concepedia

Signal Bistability

Signal Bistability is a dynamic systems-level property in signal transduction networks wherein two discrete, stable molecular signaling states can persist indefinitely under identical external conditions, enabling switch-like cellular decision-making.

43

Publications

4.4K

Citations

148

Authors

82

Institutions

Publications per year

2017–2026

10

Parents

Publications

43

Emergent Properties of Networks of Biological Signaling Pathways

Upinder S. Bhalla, Ravi Iyengar · Science · 1999 · 1.7K citations · Full text

, , +17

A mechanism for memory storage insensitive to molecular turnover: a bistable autophosphorylating kinase.

John Lisman · Proceedings of the National Academy of Sciences · 1985 · 483 citations · Full text

, , +14

A bistable Rb–E2F switch underlies the restriction point

Guang Yao, Tae Jun Lee, Seiichi Mori et al. · Nature Cell Biology · 2008 · 462 citations

, , +6

Bistability and Oscillations in the Huang-Ferrell Model of MAPK Signaling

Liang Qiao, Robert B. Nachbar, Ioannis G. Kevrekidis et al. · PLoS Computational Biology · 2007 · 216 citations · Full text

, , +17

Attractor analysis of asynchronous Boolean models of signal transduction networks

Assieh Saadatpour, István Albert, Réka Albert · Journal of Theoretical Biology · 2010 · 188 citations

, , +15

1–5 of 43

Authors

148

  1. RI
    Ravi Iyengar

    Icahn School of Medicine at Mount Sinai, United States

    2 publications · 1.8K citations

    2

    h-index

  2. SS
    Saad S. M. Hassan

    Ain Shams University, Egypt

    2 publications · 147 citations

    2

    h-index

  3. JK
    J. Krishnan

    Imperial College London, United Kingdom

    2 publications · 25 citations

    2

    h-index

  4. US
    Upinder S. Bhalla

    National Centre for Biological Sciences, India

    2 publications · 1.8K citations

    2

    h-index

  5. LY
    Lingchong You

    Duke University, United States

    1 publications · 462 citations

    1

    h-index

1–5 of 148

Institutions

82

  1. Icahn School of Medicine at Mount Sinai

    New York, United States

    2 h-index

    3 publications

    3.5K citations

  2. Imperial College London

    London, United Kingdom

    2 h-index

    3 publications

    38 citations

  3. Michigan State University

    East Lansing, United States

    2 h-index

    4 publications

    136 citations

  4. Centre National de la Recherche Scientifique

    Paris, France

    2 h-index

    4 publications

    174 citations

  5. University of Pennsylvania

    Philadelphia, United States

    2 h-index

    4 publications

    100 citations

  6. University of Liège

    Liège, Belgium

    2 h-index

    4 publications

    138 citations

  7. University of Kentucky

    Lexington, United States

    1 h-index

    4 publications

    248 citations

  8. Thomas Jefferson University

    Philadelphia, United States

    1 h-index

    4 publications

    356 citations

1–8 of 82

Venues

  1. Optics Communications

    3 publications · 162 citations

    3

    h-index

  2. Scientific Reports

    3 publications · 143 citations

    3

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 2 publications · 498 citations

    2

    h-index

  4. PLoS Computational Biology

    2 publications · 276 citations

    2

    h-index

  5. BMC Systems Biology

    2 publications · 37 citations

    2

    h-index

1–5