Concepedia

Sequence-function Analysis

Sequence-Function Analysis is a methodological framework in molecular evolution and protein engineering that establishes quantitative relationships between nucleic acid or protein sequences and their functional phenotypes derived from high-throughput selection experiments such as ribosome display.

105

Publications

8.5K

Citations

473

Authors

211

Institutions

Publications per year

2017–2026

40

Parents

Publications

105

tRNAscan-SE 2.0: improved detection and functional classification of transfer RNA genes

Patricia P. Chan, Brian Y Lin, Allysia J. Mak et al. · Nucleic Acids Research · 2021 · 1.9K citations · Full text

, , +13

Applications for protein sequence-function evolution data: mRNA/protein expression analysis and coding SNP scoring tools

Paul D. Thomas, Anish Kejariwal, Nan Guo et al. · Nucleic Acids Research · 2006 · 517 citations · Full text

, , +15

Graphic methods to determine the function of nucleic acid sequences

Rodger Staden · Nucleic Acids Research · 1984 · 364 citations · Full text

, , +11

Shifting mutational constraints in the SARS-CoV-2 receptor-binding domain during viral evolution

Tyler N. Starr, Allison J. Greaney, William W. Hannon et al. · Science · 2022 · 338 citations · Full text

, , +17

Method for prediction of protein function from sequence using the sequence-to-structure-to-function paradigm with application to Glutaredoxins/Thioredoxins and T 1 Ribonucleases 1 1Edited by F. Cohen

Jacquelyn S. Fetrow, Jeffrey Skolnick · Journal of Molecular Biology · 1998 · 209 citations

, , +15

1–5 of 105

Authors

473

  1. CS
    Chris Sander

    Memorial Sloan Kettering Cancer Center, United States

    4 publications · 162 citations

    4

    h-index

  2. PA
    Philip A. Romero

    University of Wisconsin–Madison, United States

    3 publications · 164 citations

    3

    h-index

  3. JP
    Jürgen Pleiss

    University of Stuttgart, Germany

    3 publications · 117 citations

    3

    h-index

  4. GT
    Gregg T. Beckham

    National Laboratory of the Rockies, United States

    3 publications · 81 citations

    3

    h-index

  5. JE
    Japheth E. Gado

    National Laboratory of the Rockies, United States

    3 publications · 81 citations

    3

    h-index

1–5 of 473

Institutions

211

  1. Harvard University

    Cambridge, United States

    6 h-index

    25 publications

    1.5K citations

  2. University of Wisconsin–Madison

    Madison, United States

    6 h-index

    30 publications

    1.5K citations

  3. Massachusetts Institute of Technology

    Cambridge, United States

    5 h-index

    9 publications

    879 citations

  4. Howard Hughes Medical Institute

    Chevy Chase, United States

    4 h-index

    8 publications

    1.2K citations

  5. National Institutes of Health

    Bethesda, United States

    4 h-index

    10 publications

    866 citations

  6. Center for Systems Biology

    Boston, United States

    4 h-index

    17 publications

    671 citations

  7. Wellcome Trust

    London, United Kingdom

    3 h-index

    5 publications

    144 citations

  8. National Laboratory of the Rockies

    Golden, United States

    3 h-index

    6 publications

    162 citations

1–8 of 211

Venues

  1. Nucleic Acids Research

    14 publications · 3.3K citations

    13

    h-index

  2. bioRxiv (Cold Spring Harbor Laboratory)

    Repository · 7 publications · 221 citations

    7

    h-index

  3. Nature Communications

    6 publications · 583 citations

    6

    h-index

  4. PLoS ONE

    6 publications · 246 citations

    6

    h-index

  5. Bioinformatics

    4 publications · 189 citations

    4

    h-index

1–5