Concepedia

Sequence Determinants Of Phase Separation

Sequence Determinants of Phase Separation is a theoretical construct in molecular biophysics that identifies the specific amino acid sequence features responsible for driving the formation of biomolecular condensates through liquid-liquid phase separation.

77

Publications

10.2K

Citations

371

Authors

142

Institutions

Publications per year

2017–2026

66

Parents

Publications

77

Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins

Yuan Lin, David S.W. Protter, Michael K. Rosen et al. · Molecular Cell · 2015 · 1.7K citations · Full text

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Valence and patterning of aromatic residues determine the phase behavior of prion-like domains

Erik Martin, Alex S. Holehouse, Ivan Peran et al. · Science · 2020 · 1.3K citations · Full text

, , +16

Sequence Determinants of Intracellular Phase Separation by Complex Coacervation of a Disordered Protein

Chi W. Pak, Martyna Kosno, Alex S. Holehouse et al. · Molecular Cell · 2016 · 863 citations · Full text

, , +17

Intrinsically disordered sequences enable modulation of protein phase separation through distributed tyrosine motifs

Yuan Lin, Simon L. Currie, Michael K. Rosen · Journal of Biological Chemistry · 2017 · 453 citations · Full text

, , +16

Relationship of Sequence and Phase Separation in Protein Low-Complexity Regions

Erik Martin, Tanja Mittag · Biochemistry · 2018 · 429 citations · Full text

, , +17

1–5 of 77

Authors

371

  1. JM
    Jeetain Mittal

    Lehigh University, United States

    8 publications · 695 citations

    8

    h-index

  2. RV
    Rohit V. Pappu

    Washington University in St. Louis, United States

    6 publications · 2.3K citations

    6

    h-index

  3. TM
    Tanja Mittag

    St. Jude Children's Research Hospital, United States

    4 publications · 1.8K citations

    4

    h-index

  4. NL
    Nicolas L. Fawzi

    Brown University, United States

    3 publications · 281 citations

    3

    h-index

  5. MK
    Michael K. Rosen

    The University of Texas Southwestern Medical Center, United States

    3 publications · 3K citations

    3

    h-index

1–5 of 371

Institutions

142

  1. Washington University in St. Louis

    St Louis, United States

    9 h-index

    23 publications

    9.7K citations

  2. Texas A&M University

    College Station, United States

    6 h-index

    20 publications

    1.3K citations

  3. Living Systems (United States)

    Saint Albans, United States

    5 h-index

    8 publications

    6.1K citations

  4. Howard Hughes Medical Institute

    Chevy Chase, United States

    5 h-index

    18 publications

    14.9K citations

  5. The University of Texas Southwestern Medical Center

    Dallas, United States

    4 h-index

    13 publications

    10.4K citations

  6. University of Toronto

    Toronto, Canada

    4 h-index

    17 publications

    1.1K citations

  7. St. Jude Children's Research Hospital

    Memphis, United States

    4 h-index

    15 publications

    7.6K citations

  8. Brown University

    Providence, United States

    3 h-index

    14 publications

    1.4K citations

1–8 of 142

Venues

  1. Nature Communications

    5 publications · 568 citations

    5

    h-index

  2. bioRxiv (Cold Spring Harbor Laboratory)

    Repository · 5 publications · 153 citations

    5

    h-index

  3. The Journal of Physical Chemistry B

    4 publications · 267 citations

    4

    h-index

  4. Nucleic Acids Research

    4 publications · 671 citations

    4

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 3 publications · 433 citations

    3

    h-index

1–5