Concepedia

Self-renewal Variability

Self-Renewal Variability is a theoretical construct in cancer stem cell biology that denotes the inherent heterogeneity in the capacity of individual cancer stem cells to undergo asymmetric or symmetric division and sustain clonal propagation, thereby differentiating it from uniform self-renewal models by accounting for functional diversity within the cancer stem cell population.

8

Publications

527

Citations

32

Authors

17

Institutions

Publications per year

2017–2026

3

Parents

Publications

8

Individual stem cells with highly variable proliferation and self-renewal properties comprise the human hematopoietic stem cell compartment

Joby L. McKenzie, Olga I. Gan, Monica Doedens et al. · Nature Immunology · 2006 · 162 citations

, , +17

The heterogeneity of mesenchymal stem cells: an important issue to be addressed in cell therapy

Jingxuan Li, Zewen Wu, Li Zhao et al. · Stem Cell Research & Therapy · 2023 · 134 citations · Full text

, , +11

Cancer self remission and tumor stability – a stochastic approach

Ram Rup Sarkar, Sandip Banerjee · Mathematical Biosciences · 2005 · 129 citations

, , +14

Synergistic Effect of Medium, Matrix, and Exogenous Factors on the Adhesion and Growth of Human Pluripotent Stem Cells Under Defined, Xeno-Free Conditions

Guoliang Meng, Shiying Liu, Derrick E. Rancourt · Stem Cells and Development · 2011 · 49 citations

, , +16

Modeling large fluctuations of thousands of clones during hematopoiesis: The role of stem cell self-renewal and bursty progenitor dynamics in rhesus macaque

Song Xu, Sanggu Kim, Irvin S. Y. Chen et al. · PLoS Computational Biology · 2018 · 17 citations · Full text

, , +17

1–5 of 8

Authors

32

  1. RV
    Renato Vieira dos Santos

    Universidade Federal de Minas Gerais, Brazil

    1 publications · 15 citations

    1

    h-index

  2. RP
    Robert P. Nelson

    Indiana University – Purdue University Indianapolis, United States

    1 publications · 11 citations

    1

    h-index

  3. YS
    Yazhen Su

    Shanxi Academy of Medical Sciences, China

    1 publications · 134 citations

    1

    h-index

  4. YL
    Yang Liu

    Shanxi Academy of Medical Sciences, China

    1 publications · 134 citations

    1

    h-index

  5. JE
    John E. Dick

    University of Toronto, Canada

    1 publications · 162 citations

    1

    h-index

1–5 of 32

Institutions

17

  1. University of California, Los Angeles

    Los Angeles, United States

    1 h-index

    2 publications

    34 citations

  2. Indian Statistical Institute

    Kolkata, India

    1 h-index

    1 publications

    129 citations

  3. University Health Network

    Toronto, Canada

    1 h-index

    5 publications

    810 citations

  4. The Ohio State University

    Columbus, United States

    1 h-index

    1 publications

    17 citations

  5. Universidade Federal de Minas Gerais

    Belo Horizonte, Brazil

    1 h-index

    2 publications

    30 citations

  6. Indiana University – Purdue University Indianapolis

    Indianapolis, United States

    1 h-index

    1 publications

    11 citations

  7. West German Heart and Vascular Center Essen

    Essen, Germany

    1 h-index

    2 publications

    20 citations

  8. Stanford University

    Stanford, United States

    1 h-index

    2 publications

    34 citations

1–8 of 17

Venues

  1. PLoS ONE

    1 publications · 15 citations

    1

    h-index

  2. Stem Cell Research & Therapy

    1 publications · 134 citations

    1

    h-index

  3. Stem Cells and Development

    1 publications · 49 citations

    1

    h-index

  4. Journal of Cellular Physiology

    1 publications · 10 citations

    1

    h-index

  5. PLoS Computational Biology

    1 publications · 17 citations

    1

    h-index

1–5